FAM81A

FAM81A
Identifiers
Aliases	FAM81A , family with sequence similarity 81 member A
External IDs	MGI: 1924136; HomoloGene: 17584; GeneCards: FAM81A; OMA:FAM81A - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q22.2 Start 59,372,693 bp [1] End 59,523,555 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 D Start 69,995,793 bp [2] End 70,049,842 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 9 prefrontal cortex cingulate gyrus anterior cingulate cortex middle temporal gyrus right frontal lobe primary visual cortex Brodmann area 23 right uterine tube rectum Top expressed in Epithelium of choroid plexus piriform cortex temporal lobe amygdala primary motor cortex Region I of hippocampus proper fourth ventricle choroid plexus of fourth ventricle prefrontal cortex visual cortex More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 145773 76886 Ensembl ENSG00000157470 ENSMUSG00000032224 UniProt Q8TBF8 Q3UXZ6 RefSeq (mRNA) NM_152450 NM_029784 RefSeq (protein) NP_689663 NP_084060 Location (UCSC) Chr 15: 59.37 – 59.52 Mb Chr 9: 70 – 70.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FAM81A is a protein that in humans is encoded by the FAM81A gene which is expressed in the postsynaptic density of the brain. It plays a pivotal role in forming postsynaptic protein agglomerations, essential for synaptic function in the brain. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000157470 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032224 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dosemeci A, Loo HK, Toy D, Winters CA, Reese TS, Tao-Cheng JH (April 2019). "FAM81A protein, a novel component of the postsynaptic density in adult brain". Neuroscience Letters. 699: 122–126. doi:10.1016/j.neulet.2019.02.003. PMC   6443461 . PMID   30735723.
6. Zhang Q, Sun S, Xie Q, Wang X, Qian J, Yao J, et al. (May 2022). "FAM81A identified as a stemness-related gene by screening DNA methylation sites based on machine learning-accessed stemness in pancreatic cancer". Epigenomics. 14 (10): 569–588. doi:10.2217/epi-2022-0098. PMID   35574683. S2CID   248813424.
7. Kaizuka T, Hirouchi T, Saneyoshi T, Shirafuji T, Collins MO, Grant SG, et al. (March 2024). Kim E (ed.). "FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation". PLOS Biology. 22 (3) e3002006. doi: 10.1371/journal.pbio.3002006 . PMC   10919877 . PMID   38452102.