FARSA (gene)

FARSA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L4G
Identifiers
Aliases	FARSA , CML33, FARSL, FARSLA, FRSA, PheHA, phenylalanyl-tRNA synthetase alpha subunit, phenylalanyl-tRNA synthetase subunit alpha, RILDBC2
External IDs	OMIM: 602918 MGI: 1913840 HomoloGene: 3280 GeneCards: FARSA
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.13 Start 12,922,479 bp [1] End 12,934,037 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 C3 Start 85,583,618 bp [2] End 85,595,886 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex cingulate gyrus Brodmann area 9 Brodmann area 10 gastrocnemius muscle ganglionic eminence frontal pole anterior pituitary stromal cell of endometrium Right adrenal gland Top expressed in spermatocyte spermatid morula yolk sac lip esophagus superior frontal gyrus neural tube proximal tubule mirror More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity tRNA binding nucleotide binding ligase activity protein binding ATP binding phenylalanine-tRNA ligase activity RNA binding Cellular component cytoplasm cytosol membrane phenylalanine-tRNA ligase complex Biological process tRNA aminoacylation protein biosynthesis protein heterotetramerization tRNA aminoacylation for protein translation phenylalanyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2193 66590 Ensembl ENSG00000179115 ENSMUSG00000003808 UniProt Q9Y285 Q8C0C7 RefSeq (mRNA) NM_004461 NM_025648 RefSeq (protein) NP_004452 NP_079924 Location (UCSC) Chr 19: 12.92 – 12.93 Mb Chr 8: 85.58 – 85.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phenylalanyl-tRNA synthetase alpha chain is an enzyme that in humans is encoded by the FARSA gene. ^{[5] [6]}

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000179115 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003808 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA (Jul 1997). "Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent". Proc Natl Acad Sci U S A. 94 (12): 6164–9. Bibcode:1997PNAS...94.6164S. doi: 10.1073/pnas.94.12.6164 . PMC   21020 . PMID   9177188.
6. "Entrez Gene: FARSA phenylalanyl-tRNA synthetase, alpha subunit".

Further reading

• Rodova M, Ankilova V, Safro MG (1999). "Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells". Biochem. Biophys. Res. Commun. 255 (3): 765–73. doi:10.1006/bbrc.1999.0141. PMID   10049785.
• Sang Lee J, Gyu Park S, Park H, et al. (2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID   11829477.
• Moor N, Linshiz G, Safro M (2002). "Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes". Protein Expr. Purif. 24 (2): 260–7. doi:10.1006/prep.2001.1560. PMID   11858721.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.