FBXL5

FBXL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U9J, 3U9M, 3V5X, 3V5Y, 3V5Z
Identifiers
Aliases	FBXL5 , FBL4, FBL5, FLR1, F-box and leucine-rich repeat protein 5, F-box and leucine rich repeat protein 5
External IDs	OMIM: 605655 MGI: 2152883 HomoloGene: 8129 GeneCards: FBXL5
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4p15.32 Start 15,604,381 bp [1] End 15,681,679 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B3 Start 43,901,957 bp [2] End 43,978,980 bp [2]
RNA expression pattern Bgee Top expressed in monocyte Achilles tendon kidney tubule blood seminal vesicula Germinal epithelium oocyte secondary oocyte sperm bronchial epithelial cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding GO:0001948 protein binding metal ion binding ubiquitin-protein transferase activity Cellular component ubiquitin ligase complex cytoplasm SCF ubiquitin ligase complex perinuclear region of cytoplasm cytosol Biological process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination iron ion homeostasis protein polyubiquitination cellular iron ion homeostasis post-translational protein modification ubiquitin-dependent protein catabolic process positive regulation of cellular protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26234	242960
Ensembl	ENSG00000118564	ENSMUSG00000039753
UniProt	Q9UKA1	Q8C2S5
RefSeq (mRNA)	NM_001193534 NM_001193535 NM_012161	NM_001159963 NM_178729
RefSeq (protein)	NP_001180463 NP_001180464 NP_036293	NP_001153435 NP_848844
Location (UCSC)	Chr 4: 15.6 – 15.68 Mb	Chr 5: 43.9 – 43.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene. ^{[5] [6]}

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants. ^[6]

FBXL5 is an iron sensor. It promotes IRP2 ubiquitination and then its degradation.

References

1. GRCh38: Ensembl release 89: ENSG00000118564 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039753 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi: 10.1016/S0960-9822(00)80020-2 . PMID   10531035. S2CID   7467493.
6. "Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi: 10.1016/S0960-9822(00)80021-4 . PMID   10531037. S2CID   14341845.
• Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (2001). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics. 67 (1): 40–7. doi:10.1006/geno.2000.6211. PMID   10945468.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Zhang N, Liu J, Ding X, et al. (2007). "FBXL5 interacts with p150Glued and regulates its ubiquitination". Biochem. Biophys. Res. Commun. 359 (1): 34–9. doi:10.1016/j.bbrc.2007.05.068. PMID   17532294.