FBXO28

FBXO28
Identifiers
Aliases	FBXO28 , CENP-30, Fbx28, F-box protein 28, DEE100
External IDs	OMIM: 609100 MGI: 1261890 HomoloGene: 9050 GeneCards: FBXO28
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q42.11 Start 224,114,111 bp [1] End 224,162,047 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H5|1 84.93 cM Start 182,140,667 bp [2] End 182,169,194 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle endothelial cell kidney tubule Achilles tendon Brodmann area 23 tibia germinal epithelium middle temporal gyrus vulva visceral pleura Top expressed in secondary oocyte external carotid artery internal carotid artery lacrimal gland submandibular gland motor neuron parotid gland retinal pigment epithelium medial ganglionic eminence iris More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 23219 67948 Ensembl ENSG00000143756 ENSMUSG00000047539 UniProt Q9NVF7 Q8BIG4 RefSeq (mRNA) NM_001136115 NM_015176 NM_175127 RefSeq (protein) NP_001129587 NP_055991 NP_780336 Location (UCSC) Chr 1: 224.11 – 224.16 Mb Chr 1: 182.14 – 182.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

F-box only protein 28 is a protein that in humans is encoded by the FBXO28 gene. ^{[5] [6]}

Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000143756 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047539 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID   9455484.
6. "Entrez Gene: FBXO28 F-box protein 28".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC   525538 . PMID   15520277.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.