FBXW10

FBXW10
Identifiers
Aliases	FBXW10 , Fbw10, HREP, SM25H2, SM2SH2, F-box and WD repeat domain containing 10
External IDs	OMIM: 611679; MGI: 3052463; HomoloGene: 32757; GeneCards: FBXW10; OMA:FBXW10 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p11.2 Start 18,744,026 bp [1] End 18,779,349 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B2 Start 62,737,895 bp [2] End 62,768,291 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis olfactory zone of nasal mucosa right uterine tube right adrenal cortex cerebellar hemisphere right hemisphere of cerebellum right lobe of liver gastrocnemius muscle Top expressed in seminiferous tubule spermatid spermatocyte embryo zygote secondary oocyte embryo thymus primary oocyte visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity Cellular component cytosol Biological process protein polyubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10517 213980 Ensembl ENSG00000171931 ENSMUSG00000090173 UniProt Q5XX13 Q5SUS0 RefSeq (mRNA) NM_001267585 NM_001267586 NM_031456 NM_001033669 NM_001291441 RefSeq (protein) NP_001254514 NP_001254515 NP_001028841 NP_001278370 NP_001391704 NP_001391705 NP_001391706 NP_001391707 Location (UCSC) Chr 17: 18.74 – 18.78 Mb Chr 11: 62.74 – 62.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene. ^{[5] [6] [7]}

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM] ^[7] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID 20498703).

References

1. GRCh38: Ensembl release 89: ENSG00000171931 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000090173 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics. 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID   9787083.
6. Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995). "Single test for two hereditary neuropathies, CMT1A and HNPP". Clin Chem. 41 (10): 1534–5. doi: 10.1093/clinchem/41.10.1534 . PMID   7586531.
7. "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC   525538 . PMID   15520277.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.