FBXW5

FBXW5
Identifiers
Aliases	FBXW5 , Fbw5, F-box and WD repeat domain containing 5
External IDs	OMIM: 609072; MGI: 1354731; HomoloGene: 8496; GeneCards: FBXW5; OMA:FBXW5 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.3 Start 136,940,435 bp [1] End 136,944,738 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A3 Start 25,390,762 bp [2] End 25,395,483 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis apex of heart popliteal artery tibial arteries muscle of thigh gastrocnemius muscle granulocyte right lobe of liver right coronary artery Top expressed in spermatocyte spermatid seminiferous tubule muscle of thigh entorhinal cortex superior frontal gyrus primary visual cortex saccule perirhinal cortex right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein kinase binding ubiquitin-protein transferase activity Cellular component Cul4-RING E3 ubiquitin ligase complex cytoplasm SCF ubiquitin ligase complex cytosol Biological process proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination regulation of centrosome duplication SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein polyubiquitination regulation of mitotic nuclear division post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54461 30839 Ensembl ENSG00000159069 ENSMUSG00000015095 UniProt Q969U6 Q9QXW2 RefSeq (mRNA) NM_018998 NM_178225 NM_178226 NM_013908 NM_001356407 NM_001356408 RefSeq (protein) NP_061871 NP_038936 NP_001343336 NP_001343337 Location (UCSC) Chr 9: 136.94 – 136.94 Mb Chr 2: 25.39 – 25.4 Mb PubMed search [3] [4]
Wikidata
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F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene. ^[5]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated Messenger RNA decay candidates, hence not represented. ^[5] Well established targets of FBXW5 include TSC2 ^[6] and SEC23B. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000159069 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015095 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FBXW5 F-box and WD repeat domain containing 5".
6. Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, et al. (April 2008). "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase". Genes & Development. 22 (7): 866–71. doi:10.1101/gad.1624008. PMC   2279197 . PMID   18381890.
7. Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, et al. (December 2018). "The ULK1-FBXW5-SEC23B nexus controls autophagy". eLife. 7. doi: 10.7554/eLife.42253 . PMC   6351106 . PMID   30596474.

Further reading

• Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi: 10.1016/S0960-9822(00)80020-2 . PMID   10531035. S2CID   7467493.
• Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (October 1999). "A family of mammalian F-box proteins". Current Biology. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi: 10.1016/S0960-9822(00)80021-4 . PMID   10531037. S2CID   14341845.
• Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, et al. (March 2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP". Proceedings of the National Academy of Sciences of the United States of America. 101 (13): 4419–24. Bibcode:2004PNAS..101.4419W. doi: 10.1073/pnas.0307700101 . PMC   384762 . PMID   15070733.