FCHSD2

FCHSD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DL5, 2DL7
Identifiers
Aliases	FCHSD2 , NWK, SH3MD3, FCH and double SH3 domains 2, NWK1
External IDs	OMIM: 617556; MGI: 2448475; HomoloGene: 8887; GeneCards: FCHSD2; OMA:FCHSD2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.4 Start 72,836,745 bp [1] End 73,142,318 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E2 Start 100,742,070 bp [2] End 100,933,612 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries lymph node right coronary artery Descending thoracic aorta ascending aorta ventricular zone right lung left coronary artery appendix Top expressed in zygote mesenteric lymph nodes secondary oocyte primary oocyte habenula paraventricular nucleus of hypothalamus otolith organ trigeminal ganglion utricle epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3,4-bisphosphate binding lipid binding Cellular component neuromuscular junction recycling endosome plasma membrane clathrin-coated pit stereocilium shaft cytoplasm membrane cell junction stereocilium cell projection Biological process neuromuscular synaptic transmission regulation of actin filament polymerization positive regulation of actin filament polymerization clathrin-dependent endocytosis positive regulation of Arp2/3 complex-mediated actin nucleation endocytosis protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9873 207278 Ensembl ENSG00000137478 ENSMUSG00000030691 UniProt O94868 Q3USJ8 RefSeq (mRNA) NM_014824 NM_001146010 NM_199012 RefSeq (protein) NP_055639 NP_001139482 NP_950177 Location (UCSC) Chr 11: 72.84 – 73.14 Mb Chr 7: 100.74 – 100.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FCH and double SH3 domains protein 2 is a protein that in humans is encoded by the FCHSD2 gene. ^{[5] [6] [7]}

Interactions

FCHSD2 has been shown to interact with MAGI1 ^[8] and C2orf73. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000137478 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030691 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID   9872452.
6. Katoh M, Katoh M (May 2004). "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico". International Journal of Molecular Medicine. 13 (5): 749–54. doi:10.3892/ijmm.13.5.749. PMID   15067381.
7. "Entrez Gene: FCHSD2 FCH and double SH3 domains 2".
8. Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (November 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID   14627983. S2CID   6289557.
9. Thalappilly S, Suliman M, Gayet O, Soubeyran P, Hermant A, Lecine P, Iovanna JL, Dusetti NJ (August 2008). "Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach". Proteomics. 8 (15): 3071–81. doi:10.1002/pmic.200701157. PMID   18654987. S2CID   25344443.

Further reading

• Petitjean C, Scheydeker JL, Suinat JL, Rendoing J (1976). "[Pulmonary edema in hangings]". De l'Anesthésiologie Française. 16. 16 Spec No 2-3: 57–65. PMID   9873.
• Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (November 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID   14627983. S2CID   6289557.
• Coyle IP, Koh YH, Lee WC, Slind J, Fergestad T, Littleton JT, Ganetzky B (February 2004). "Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila". Neuron. 41 (4): 521–34. doi: 10.1016/S0896-6273(04)00016-9 . PMID   14980202. S2CID   797812.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y (March 2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi: 10.1038/nature04632 . PMID   16554811.