FCRLA

FCRLA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HWN
Identifiers
Aliases	FCRLA , FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB, Fc receptor like A
External IDs	OMIM: 606891 MGI: 2138647 HomoloGene: 13106 GeneCards: FCRLA
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.3 Start 161,706,972 bp [1] End 161,714,352 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H3 Start 170,745,145 bp [2] End 170,755,152 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node spleen appendix superficial temporal artery pancreatic ductal cell bone marrow cells blood thymus cancellous bone rectum Top expressed in spleen blood spermatocyte bone marrow subcutaneous adipose tissue thymus spermatid left colon seminiferous tubule jejunum More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 84824 98752 Ensembl ENSG00000132185 ENSMUSG00000038421 UniProt Q7L513 Q920A9 RefSeq (mRNA) NM_001184866 NM_001184867 NM_001184870 NM_001184871 NM_001184872 NM_001184873 NM_032738 NM_001366195 NM_001366196 NM_001160215 NM_145141 RefSeq (protein) NP_001171795 NP_001171796 NP_001171799 NP_001171800 NP_001171801 NP_001171802 NP_116127 NP_001353124 NP_001353125 NP_001153687 NP_660123 Location (UCSC) Chr 1: 161.71 – 161.71 Mb Chr 1: 170.75 – 170.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene. ^{[5] [6]}

Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000132185 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038421 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV (Dec 2001). "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features". Eur J Immunol. 32 (1): 87–96. doi:10.1002/1521-4141(200201)32:1<87::AID-IMMU87>3.0.CO;2-#. PMID   11754007. S2CID   196599868.
6. "Entrez Gene: FCRLA Fc receptor-like A".

Further reading

• Facchetti F, Cella M, Festa S, et al. (2002). "An unusual Fc receptor-related protein expressed in human centroblasts". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3776–81. Bibcode:2002PNAS...99.3776F. doi: 10.1073/pnas.022042699 . PMC   122600 . PMID   11891275.
• Davis RS, Li H, Chen CC, et al. (2003). "Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells". Int. Immunol. 14 (9): 1075–83. doi: 10.1093/intimm/dxf074 . PMID   12202404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Huizinga TW, Ioan-Facsinay A (2004). "Soluble FcgammaRIIIa as a marker for rheumatoid arthritis: the use of genetics in selected populations to study pathogenetic pathways". J. Rheumatol. 30 (9): 1904–6. PMID   12966588.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Inozume T, Matsuzaki Y, Kurihara S, et al. (2005). "Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients". Int. J. Cancer. 114 (2): 283–90. doi: 10.1002/ijc.20735 . PMID   15551350.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID   17273841. S2CID   1971426.