FERM and PDZ domain containing 2

FRMPD2
Identifiers
Aliases	FRMPD2 , PDZD5C, PDZK4, PDZK5C, FERM and PDZ domain containing 2
External IDs	OMIM: 613323 MGI: 2685472 HomoloGene: 51854 GeneCards: FRMPD2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	48,274,696 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	33,297,226 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; right uterine tube; ; corpus callosum; ; prefrontal cortex; ; hypothalamus; ; temporal lobe; ; amygdala;
	Top expressed in
	retinal pigment epithelium; ; pineal gland; ; secondary oocyte; ; ciliary body; ; autonomic nervous system; ; Geniculate ganglion; ; sympathetic ganglion; ; paravertebral ganglia; ; paraventricular nucleus of hypothalamus; ; olfactory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; 1-phosphatidylinositol binding ;
Cellular component	membrane ; cell junction ; cytoskeleton ; cytoplasm ; plasma membrane ; basolateral plasma membrane ; bicellular tight junction ;
Biological process	bicellular tight junction assembly ;
	Sources:Amigo / QuickGO
Orthologs
	143162
	268729
	ENSG00000170324
	ENSMUSG00000108841
	Q68DX3
	n/a
	NM_001017929 ; NM_001018071 ; NM_001042512 ; NM_152428 ; NM_001318191 Contents Function ; References ; Further reading ;
	XM_017316244 ; XM_036158980 ; XM_036158982
	NP_001018081 ; NP_001035977 ; NP_001305120
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

FERM and PDZ domain containing 2 is a protein that in humans is encoded by the FRMPD2 gene. ^[5]

Function

This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170324 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000108841 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: FERM and PDZ domain containing 2" . Retrieved 2017-09-05.

FERM and PDZ domain containing 2

Contents

Function

Related Research Articles

References

Further reading