FEZ1

FEZ1
Identifiers
Aliases	FEZ1 , UNC-76, fasciculation and elongation protein zeta 1
External IDs	OMIM: 604825; MGI: 2670976; HomoloGene: 21063; GeneCards: FEZ1; OMA:FEZ1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q24.2 Start 125,442,881 bp [1] End 125,592,568 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A4 Start 36,733,160 bp [2] End 36,790,220 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior olivary nucleus C1 segment inferior ganglion of vagus nerve corpus callosum middle frontal gyrus subthalamic nucleus prefrontal cortex pons dorsal motor nucleus of vagus nerve substantia nigra Top expressed in deep cerebellar nuclei globus pallidus ventricular zone lobe of cerebellum cerebellar vermis inferior colliculi superior colliculus lateral geniculate nucleus ganglionic eminence medulla oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding gamma-tubulin binding protein kinase C binding protein N-terminus binding Cellular component centrosome Golgi apparatus cell projection membrane plasma membrane microtubule organizing center dendrite mitochondrion microtubule cytoskeleton cytoplasm axon growth cone soma microtubule cytoskeleton Biological process negative regulation of autophagosome assembly cellular response to growth factor stimulus nervous system development axon guidance cell adhesion establishment of mitochondrion localization positive regulation of neuron differentiation positive regulation of neuron projection development hippocampus development establishment of cell polarity positive regulation of anterograde axonal transport of mitochondrion mitochondrion morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9638 235180 Ensembl ENSG00000149557 ENSMUSG00000032118 UniProt Q99689 Q8K0X8 RefSeq (mRNA) NM_005103 NM_022549 NM_183171 NM_001357610 NM_001357611 NM_001357612 NM_001357613 NM_001357614 RefSeq (protein) NP_005094 NP_072043 NP_898994 NP_001344539 NP_001344540 NP_001344541 NP_001344542 NP_001344543 Location (UCSC) Chr 11: 125.44 – 125.59 Mb Chr 9: 36.73 – 36.79 Mb PubMed search [3] [4]
Wikidata
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Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene. ^{[5] [6] [7]}

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. ^[7]

This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV. ^[8]

Interactions

FEZ1 has been shown to interact with Protein kinase Mζ, ^[9] NBR1 ^[10] and DISC1. ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000149557 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032118 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi: 10.1073/pnas.94.7.3414 . PMC   20384 . PMID   9096408.
6. Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K, Sawa H (Jun 2005). "Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation". J Biol Chem. 280 (26): 24948–56. doi: 10.1074/jbc.M411499200 . PMID   15843383.
7. "Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)".
8. Haedicke, J.; Brown, C.; Naghavi, M. H. (Aug 2009). "The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection". Proceedings of the National Academy of Sciences. 106 (33): 14040–14045. Bibcode:2009PNAS..10614040H. doi: 10.1073/pnas.0900502106 . ISSN   0027-8424. PMC   2729016 . PMID   19667186.
9. Kuroda, S; Nakagawa N; Tokunaga C; Tatematsu K; Tanizawa K (Feb 1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein". J. Cell Biol. 144 (3): 403–11. doi:10.1083/jcb.144.3.403. ISSN   0021-9525. PMC   2132904 . PMID   9971736.
10. Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–45. doi: 10.1046/j.0014-2956.2001.02681.x . ISSN   0014-2956. PMID   11856312.
11. Miyoshi, K; Honda A; Baba K; Taniguchi M; Oono K; Fujita T; Kuroda S; Katayama T; Tohyama M (Jul 2003). "Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth". Mol. Psychiatry. 8 (7): 685–94. doi: 10.1038/sj.mp.4001352 . ISSN   1359-4184. PMID   12874605.

Further reading

• Kuroda S, Nakagawa N, Tokunaga C, et al. (1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein". J. Cell Biol. 144 (3): 403–11. doi:10.1083/jcb.144.3.403. PMC   2132904 . PMID   9971736.
• Whitehouse C, Chambers J, Howe K, et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–45. doi: 10.1046/j.0014-2956.2001.02681.x . PMID   11856312.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Miyoshi K, Honda A, Baba K, et al. (2004). "Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth". Mol. Psychiatry. 8 (7): 685–94. doi: 10.1038/sj.mp.4001352 . PMID   12874605.
• Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID   14690447.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi: 10.1016/j.molcel.2004.09.016 . PMID   15383276.
• Okumura F, Hatakeyama S, Matsumoto M, et al. (2005). "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis". J. Biol. Chem. 279 (51): 53533–43. doi: 10.1074/jbc.M402916200 . PMID   15466860.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yamada K, Nakamura K, Minabe Y, et al. (2005). "Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts". Biol. Psychiatry. 56 (9): 683–90. doi:10.1016/j.biopsych.2004.08.015. PMID   15522253. S2CID   42525017.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. 281 (15): 9869–81. doi: 10.1074/jbc.M513280200 . PMID   16484223.
• Blasius TL, Cai D, Jih GT, et al. (2007). "Two binding partners cooperate to activate the molecular motor Kinesin-1". J. Cell Biol. 176 (1): 11–7. doi:10.1083/jcb.200605099. PMC   2063617 . PMID   17200414.
• Koga M, Ishiguro H, Horiuchi Y, et al. (2007). "Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population". Neurosci. Lett. 417 (3): 326–9. doi:10.1016/j.neulet.2007.02.055. PMID   17374448. S2CID   33689793.