FEZ2

FEZ2
Identifiers
Aliases	FEZ2 , HUM3CL, fasciculation and elongation protein zeta 2
External IDs	OMIM: 604826; MGI: 2675856; HomoloGene: 3742; GeneCards: FEZ2; OMA:FEZ2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p22.2 Start 36,531,805 bp [1] End 36,646,087 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 E2- E3|17 48.57 cM Start 78,676,641 bp [2] End 78,725,581 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii thoracic diaphragm deltoid muscle parietal pleura muscle of thigh visceral pleura Brodmann area 23 Top expressed in epithelium of lens sternocleidomastoid muscle muscle of thigh triceps brachii muscle retinal pigment epithelium right ventricle temporal muscle quadriceps femoris muscle digastric muscle gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm axon Biological process signal transduction nervous system development negative regulation of autophagosome assembly axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9637 225020 Ensembl ENSG00000171055 ENSMUSG00000056121 UniProt Q9UHY8 Q6TYB5 RefSeq (mRNA) NM_001042548 NM_005102 NM_001285940 NM_001285946 NM_001285949 NM_199448 NM_001360407 RefSeq (protein) NP_001036013 NP_005093 NP_001272869 NP_001272875 NP_001272878 NP_955519 NP_001347336 Location (UCSC) Chr 2: 36.53 – 36.65 Mb Chr 17: 78.68 – 78.73 Mb PubMed search [3] [4]
Wikidata
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Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene. ^{[5] [6]}

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. ^[6]

Interactions

FEZ2 has been shown to interact with Protein kinase Mζ. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171055 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056121 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi: 10.1073/pnas.94.7.3414 . PMC   20384 . PMID   9096408.
6. "Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)".
7. Fujita, Toshitsugu; Ikuta Junko; Hamada Juri; Okajima Toshihide; Tatematsu Kenji; Tanizawa Katsuyuki; Kuroda Shun'ichi (Jan 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3). United States: 738–44. doi:10.1016/j.bbrc.2003.12.006. ISSN   0006-291X. PMID   14697253.

Further reading

• Ranes-Goldberg MG, Hori T, Mohan-Peterson S, Spits H (1993). "Identification of human pre-T/NK cell-associated genes". J. Immunol. 151 (10): 5810–21. doi:10.4049/jimmunol.151.10.5810. PMID   8228263. S2CID   39286195.
• Kolle G, Georgas K, Holmes GP, et al. (2000). "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis". Mech. Dev. 90 (2): 181–93. doi: 10.1016/S0925-4773(99)00248-8 . PMID   10642437. S2CID   6529349.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID   14690447.
• Fujita T, Ikuta J, Hamada J, et al. (2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. PMID   14697253.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. 281 (15): 9869–81. doi: 10.1074/jbc.M513280200 . PMID   16484223.