FEZ2

Last updated
FEZ2
Identifiers
Aliases FEZ2 , HUM3CL, fasciculation and elongation protein zeta 2
External IDs OMIM: 604826 MGI: 2675856 HomoloGene: 3742 GeneCards: FEZ2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042548
NM_005102

NM_001285940
NM_001285946
NM_001285949
NM_199448
NM_001360407

Contents

RefSeq (protein)

NP_001036013
NP_005093

NP_001272869
NP_001272875
NP_001272878
NP_955519
NP_001347336

Location (UCSC) Chr 2: 36.53 – 36.65 Mb Chr 17: 78.68 – 78.73 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene. [5] [6]

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [6]

Interactions

FEZ2 has been shown to interact with Protein kinase Mζ. [7]

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In molecular biology, the FEZ-like protein family is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation. The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic. The Caenorhabditis elegans homologue, UNC-76, may play structural and signalling roles in the control of axonal extension and adhesion and these roles have also been postulated for other FEZ family proteins. Certain homologues have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells. The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta. The members of this family are predicted to form coiled-coil structures which may interact with members of the RhoA family of signalling proteins, but are not thought to contain other characteristic protein motifs. Certain members of this family are expressed almost exclusively in the brain, whereas others are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171055 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056121 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi: 10.1073/pnas.94.7.3414 . PMC   20384 . PMID   9096408.
  6. 1 2 "Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)".
  7. Fujita, Toshitsugu; Ikuta Junko; Hamada Juri; Okajima Toshihide; Tatematsu Kenji; Tanizawa Katsuyuki; Kuroda Shun'ichi (Jan 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. United States. 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. ISSN   0006-291X. PMID   14697253.

Further reading