FEZ2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | FEZ2 , HUM3CL, fasciculation and elongation protein zeta 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 604826 MGI: 2675856 HomoloGene: 3742 GeneCards: FEZ2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene. [5] [6]
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [6]
FEZ2 has been shown to interact with Protein kinase Mζ. [7]
Probable G-protein coupled receptor 150 is a protein that in humans is encoded by the GPR150 gene.
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 is a protein that in humans is encoded by the SMARCD1 gene.
Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.
Ubiquitin carboxyl-terminal hydrolase isozyme L5 is an enzyme that in humans is encoded by the UCHL5 gene.
Integral membrane protein 2B is a protein that in humans is encoded by the ITM2B gene.
Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.
Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.
Diphthine synthase is an enzyme that in humans is encoded by the DPH5 gene.
Protein prune homolog 2 is a protein that in humans is encoded by the PRUNE2 gene.
Stress-associated endoplasmic reticulum protein 1 is a protein that in humans is encoded by the SERP1 gene.
COBW domain-containing protein 1 is a protein that is found in humans and mice. It is encoded by the CBWD1 gene.
Eukaryotic translation elongation factor 1 epsilon-1 is a protein that in humans is encoded by the EEF1E1 gene.
WASH complex subunit 3, formerly known as coiled-coil domain-containing protein 53 (CCDC53), is a protein that in humans is encoded by the WASHC3 gene.
B-cell receptor-associated protein 29 is a protein that in humans is encoded by the BCAP29 gene.
RNA-binding protein PNO1 is a protein that in humans is encoded by the PNO1 gene.
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase is an enzyme that in humans is encoded by the AASDHPPT gene.
39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene.
Synaptonemal complex protein 1 is a protein involved in the synaptonemal complex during meiosis, that in humans is encoded by the SYCP1 gene.
Eukaryotic translation initiation factor 1b is a protein that in humans is encoded by the EIF1B gene.
In molecular biology, the FEZ-like protein family is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation. The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic. The Caenorhabditis elegans homologue, UNC-76, may play structural and signalling roles in the control of axonal extension and adhesion and these roles have also been postulated for other FEZ family proteins. Certain homologues have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells. The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta. The members of this family are predicted to form coiled-coil structures which may interact with members of the RhoA family of signalling proteins, but are not thought to contain other characteristic protein motifs. Certain members of this family are expressed almost exclusively in the brain, whereas others are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues.