FGFBP1

FGFBP1
Identifiers
Aliases	FGFBP1 , FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17, fibroblast growth factor binding protein 1
External IDs	OMIM: 607737; MGI: 1096350; HomoloGene: 3766; GeneCards: FGFBP1; OMA:FGFBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	15,938,740 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	44,139,121 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; gums; ; gingival epithelium; ; mucosa of esophagus; ; oral cavity; ; mucosa of transverse colon; ; human penis; ; vulva; ; skin of abdomen; ; skin of leg;
	Top expressed in
	corneal stroma; ; mucous cell of stomach; ; skin of abdomen; ; epithelium of stomach; ; optic nerve; ; esophagus; ; belly cord; ; lip; ; pyloric antrum; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor binding ; heparin binding ; protein binding ; growth factor binding ;
Cellular component	extracellular region ; cell surface ; plasma membrane ; membrane ; extracellular space ;
Biological process	positive regulation of fibroblast growth factor receptor signaling pathway ; fibroblast growth factor receptor signaling pathway ; signal transduction ; positive regulation of cell population proliferation ; negative regulation of cell population proliferation ; cell-cell signaling ; positive regulation of cell migration involved in sprouting angiogenesis ; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	9982
	14181
	ENSG00000137440
	ENSMUSG00000048373
	Q14512
	O70514
	NM_005130
	NM_001271616 ; NM_008009
	NP_005121
	NP_001258545 ; NP_032035
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 09, 2024

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.^[5]^[6]^[7]

Interactions

FGFBP1 has been shown to interaction with Perlecan.^[5]

Related Research Articles

Fibroblast growth factor 1, (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

Perlecan (PLC) also known as basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) or heparan sulfate proteoglycan 2 (HSPG2), is a protein that in humans is encoded by the HSPG2 gene. The HSPG2 gene codes for a 4,391 amino acid protein with a molecular weight of 468,829. It is one of the largest known proteins. The name perlecan comes from its appearance as a "string of pearls" in rotary shadowed images.

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein.

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene.

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334.

Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are the best-characterized plasma membrane proteoglycans. Their intracellular domain of membrane-spanning core protein interacts with actin cytoskeleton and signaling molecules in the cell cortex. Syndecans are normally found on the cell surface of fibroblasts and epithelial cells. Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. Also, syndecans bind to FGFs and bring them to the FGF receptor on the same cell. As a co-receptor or regulator, mutated certain proteoglycans could cause severe developmental defects, like disordered distribution or inactivation of signaling molecules.

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.

Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene.

Syndecan-3 is a protein that in humans is encoded by the SDC3 gene.

Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene. The major function of the protein is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with low affinity compared to IGFBPs 1-6. It also stimulates cell adhesion. The protein is implicated in some cancers.

Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene.

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.

Golgi apparatus protein 1 is a protein that in humans is encoded by the GLG1 gene.

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene.

Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137440 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048373 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263–71. doi: 10.1074/jbc.M011493200 . PMID 11148217.
↑ Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25): 16778–85. doi: 10.1016/S0021-9258(18)55368-0 . PMID 1885605.
1 2 "Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

Abuharbeid S, Czubayko F, Aigner A (2006). "The fibroblast growth factor-binding protein FGF-BP". Int. J. Biochem. Cell Biol. 38 (9): 1463–8. doi:10.1016/j.biocel.2005.10.017. PMID 16324873.
Lange LG, Sytkowski AJ, Vallee BL (1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features". Biochemistry. 15 (21): 4687–93. doi:10.1021/bi00666a023. PMID 9982.
Czubayko F, Liaudet-Coopman ED, Aigner A, et al. (1997). "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer". Nat. Med. 3 (10): 1137–40. doi:10.1038/nm1097-1137. PMID 9334727. S2CID 3633113.
Wang XC, Chen JH, Crab JW, Sato JD (1998). "Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site". Biochem. Mol. Biol. Int. 46 (1): 81–7. doi: 10.1080/15216549800203582 . PMID 9784842. S2CID 44789730.
Harris VK, Coticchia CM, Kagan BL, et al. (2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways". J. Biol. Chem. 275 (15): 10802–11. doi: 10.1074/jbc.275.15.10802 . PMID 10753873.
Sauter ER, Nesbit M, Tichansky D, et al. (2001). "Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium". Int. J. Cancer. 92 (3): 374–81. doi: 10.1002/ijc.1207 . PMID 11291074. S2CID 20415335.
Chen JH, Wang XC, Sato JD (2001). "Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells". Cell Biol. Int. 25 (6): 567–70. doi:10.1006/cbir.2000.0688. PMID 11407864. S2CID 19909718.
Tassi E, Al-Attar A, Aigner A, et al. (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein". J. Biol. Chem. 276 (43): 40247–53. doi: 10.1074/jbc.M104933200 . PMID 11509569.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Beer HD, Bittner M, Niklaus G, et al. (2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair". Oncogene. 24 (34): 5269–77. doi:10.1038/sj.onc.1208560. PMID 15806171. S2CID 75364.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Xie B, Tassi E, Swift MR, et al. (2006). "Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display". J. Biol. Chem. 281 (2): 1137–44. doi: 10.1074/jbc.M510754200 . PMID 16257968.
Ray PE, Tassi E, Liu XH, Wellstein A (2006). "Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome". Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 (1): R105–13. doi:10.1152/ajpregu.00492.2005. PMID 16352855. S2CID 25248653.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000137440 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048373 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11148217-5] 1 2 Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263–71. doi: 10.1074/jbc.M011493200 . PMID 11148217.

[pmid1885605-6] Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25): 16778–85. doi: 10.1016/S0021-9258(18)55368-0 . PMID 1885605.

[entrez-7] 1 2 "Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

FGFBP1

Contents

Interactions

Related Research Articles

References

Further reading