FLVCR1

FLVCR1
Identifiers
Aliases	FLVCR1 , AXPC1, FLVCR, MFSD7B, PCA, PCARP, feline leukemia virus subgroup C cellular receptor 1, SLC49A1, FLVCR heme transporter 1
External IDs	OMIM: 609144; MGI: 2444881; HomoloGene: 56661; GeneCards: FLVCR1; OMA:FLVCR1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.3 Start 212,858,275 bp [1] End 212,899,363 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H6 Start 190,738,044 bp [2] End 190,758,355 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of ileum pancreatic epithelial cell corpus epididymis bronchial epithelial cell buccal mucosa cell duodenum germinal epithelium pylorus retinal pigment epithelium Top expressed in epithelium of small intestine ciliary body temporal muscle migratory enteric neural crest cell granulocyte triceps brachii muscle intercostal muscle ileum digastric muscle stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity protein binding heme transmembrane transporter activity heme binding Cellular component integral component of membrane mitochondrial membranes membrane plasma membrane integral component of plasma membrane mitochondrion Biological process embryonic skeletal system morphogenesis head morphogenesis limb morphogenesis multicellular organism growth embryonic digit morphogenesis in utero embryonic development mitochondrial transport spleen development heme transport multicellular organism development blood vessel development erythrocyte differentiation regulation of organ growth heme export cellular iron ion homeostasis erythrocyte maturation transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28982 226844 Ensembl ENSG00000162769 ENSMUSG00000066595 UniProt Q9Y5Y0 B2RXV4 RefSeq (mRNA) NM_014053 NM_001081259 NM_001313747 NM_198025 RefSeq (protein) NP_054772 NP_001074728 NP_001300676 NP_932142 Location (UCSC) Chr 1: 212.86 – 212.9 Mb Chr 1: 190.74 – 190.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Feline leukemia virus subgroup C receptor-related protein 1 is a protein that in humans is encoded by the FLVCR1 gene (SLC49A1). ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000162769 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066595 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tailor CS, Willett BJ, Kabat D (1999). "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily". J. Virol. 73 (8): 6500–5. doi:10.1128/JVI.73.8.6500-6505.1999. PMC   112732 . PMID   10400745.
6. Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000). "Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia". Blood. 95 (3): 1093–9. doi:10.1182/blood.V95.3.1093.003k01_1093_1099. PMID   10648427.
7. "Entrez Gene: FLVCR feline leukemia virus subgroup C cellular receptor".
8. Crielaard, Bart J.; Lammers, Twan; Rivella, Stefano (2017-02-03). "Targeting iron metabolism in drug discovery and delivery". Nature Reviews Drug Discovery. advance online publication (6): 400–423. doi:10.1038/nrd.2016.248. ISSN   1474-1784. PMC   5455971 . PMID   28154410.

Further reading

• Lipovich L, Hughes AL, King MC, Abkowitz JL, Quigley JG (2002). "Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus". Gene. 286 (2): 203–13. doi:10.1016/S0378-1119(02)00457-2. PMID   11943475.
• Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL (2004). "Identification of a human heme exporter that is essential for erythropoiesis". Cell. 118 (6): 757–66. doi: 10.1016/j.cell.2004.08.014 . PMID   15369674. S2CID   12749187.
• Quigley JG, Gazda H, Yang Z, Ball S, Sieff CA, Abkowitz JL (2006). "Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia". Blood Cells Mol. Dis. 35 (2): 189–92. doi:10.1016/j.bcmd.2005.01.005. PMID   15996880.
• Brown JK, Fung C, Tailor CS (2006). "Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1". J. Virol. 80 (4): 1742–51. doi:10.1128/JVI.80.4.1742-1751.2006. PMC   1367145 . PMID   16439531.