FNBP4

FNBP4
Identifiers
Aliases	FNBP4 , FBP30, formin binding protein 4
External IDs	OMIM: 615265 MGI: 1860513 HomoloGene: 9087 GeneCards: FNBP4
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,767,443 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	90,781,021 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; gastric mucosa; ; Achilles tendon; ; canal of the cervix; ; body of pancreas; ; right uterine tube; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; appendix; ; skin of abdomen;
	Top expressed in
	spermatocyte; ; cerebellar cortex; ; thymus; ; neural tube; ; secondary oocyte; ; superior frontal gyrus; ; lip; ; spleen; ; blood; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	More reference expression data
Orthologs
	23360
	55935
	ENSG00000109920 ; ENSG00000285182
	ENSMUSG00000008200
	Q8N3X1
	Q6ZQ03
	NM_015308 ; NM_001318339
	NM_018828
	NP_001305268 ; NP_056123
	NP_061298
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Formin-binding protein 4 is a protein that in humans is encoded by the FNBP4 gene.^[5]^[6]

Mutations in this gene have been found associated to cases similar to microphthalmia with limb anomalies (doi: 10.1002/ajmg.a.35983).

Related Research Articles

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References

1 2 3 ENSG00000285182 GRCh38: Ensembl release 89: ENSG00000109920, ENSG00000285182 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008200 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi: 10.1093/dnares/6.1.63 . PMID 10231032.
↑ "Entrez Gene: FNBP4 formin binding protein 4".

Bedford MT, Sarbassova D, Xu J, et al. (2000). "A novel pro-Arg motif recognized by WW domains". J. Biol. Chem. 275 (14): 10359–69. doi: 10.1074/jbc.275.14.10359 . PMID 10744724.
Bedford MT, Frankel A, Yaffe MB, et al. (2000). "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains". J. Biol. Chem. 275 (21): 16030–6. doi: 10.1074/jbc.M909368199 . PMID 10748127.
Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1". J. Mol. Biol. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542 . PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000285182 GRCh38: Ensembl release 89: ENSG00000109920, ENSG00000285182 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008200 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10231032-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi: 10.1093/dnares/6.1.63 . PMID 10231032.

[entrez-6] "Entrez Gene: FNBP4 formin binding protein 4".

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FNBP4

Related Research Articles

References

Further reading