FPGT | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | FPGT , GFPP, fucose-1-phosphate guanylyltransferase | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 603609 MGI: 1922790 HomoloGene: 2847 GeneCards: FPGT | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Fucose-1-phosphate guanylyltransferase is an enzyme that in humans is encoded by the FPGT gene. [5] [6]
L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell–cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose.
There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.
This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. [6]
BMP and activin membrane-bound inhibitor homolog , also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.
In enzymology, a fucose-1-phosphate guanylyltransferase is an enzyme that catalyzes the chemical reaction
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 is a protein that in humans is encoded by the GNG12 gene.
GTP cyclohydrolase 1 feedback regulatory protein is an enzyme that in humans is encoded by the GCHFR gene.
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B3GALNT1 gene.
Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.
Oligodendrocyte-myelin glycoprotein is a protein that in humans is encoded by the OMG gene.
Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene.
RAB3A-interacting protein is a protein that in humans is encoded by the RAB3IP gene.
Nucleolar GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP4 gene.
Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.
Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.
FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the FGD3 gene.
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 is a protein that in humans is encoded by the SLC35B2 gene.
GDP-fucose transporter 1 is a protein that in humans is encoded by the SLC35C1 gene.
Galactose-3-O-sulfotransferase 4 is an enzyme that in humans is encoded by the GAL3ST4 gene.
Mannose-1-phosphate guanyltransferase beta is an enzyme that in humans is encoded by the GMPPB gene.
GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene.
Epidermal growth factor receptor kinase substrate 8-like protein 3 is an enzyme that in humans is encoded by the EPS8L3 gene.
GTP binding protein 6 also known as GTPBP6 is a protein which in humans is encoded by the pseudoautosomal GTPBP6 gene.