FRAT1

Last updated
FRAT1
Protein FRAT1 PDB 1gng.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FRAT1 , WNT signaling pathway regulator, FRAT regulator of WNT signaling pathway 1
External IDs OMIM: 602503 MGI: 109450 HomoloGene: 3999 GeneCards: FRAT1
Orthologs
SpeciesHumanMouse
Entrez

10023

14296

Ensembl

ENSG00000165879

ENSMUSG00000067199

UniProt

Q92837

P70339

RefSeq (mRNA)

NM_181355
NM_005479

NM_008043

RefSeq (protein)

NP_005470

NP_032069

Location (UCSC) Chr 10: 97.32 – 97.32 Mb Chr 19: 41.82 – 41.82 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene. [5] [6]

Contents

The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis. [6]

Related Research Articles

<span class="mw-page-title-main">Adenomatous polyposis coli</span> Protein-coding gene in the species Homo sapiens

Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations in the APC gene may result in colorectal cancer.

<span class="mw-page-title-main">Catenin beta-1</span> Mammalian protein found in Homo sapiens

Catenin beta-1, also known as beta-catenin (β-catenin), is a protein that in humans is encoded by the CTNNB1 gene.

<span class="mw-page-title-main">Glycogen synthase kinase-3 beta</span>

Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the Gsk3b gene. Abnormal regulation and expression of GSK-3 beta is associated with an increased susceptibility towards bipolar disorder.

<span class="mw-page-title-main">AXIN1</span>

Axin-1 is a protein that in humans is encoded by the AXIN1 gene.

<span class="mw-page-title-main">Frizzled-5</span>

Frizzled-5(Fz-5) is a protein that in humans is encoded by the FZD5 gene.

<span class="mw-page-title-main">YES1</span>

Proto-oncogene tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene.

<span class="mw-page-title-main">DVL1</span>

Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene.

<span class="mw-page-title-main">MST1R</span>

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. MST1R is also known as RON kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.

<span class="mw-page-title-main">LRP6</span>

Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.

<span class="mw-page-title-main">WNT3A</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.

<span class="mw-page-title-main">MAGI2</span>

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.

<span class="mw-page-title-main">DVL3</span>

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.

<span class="mw-page-title-main">WNT3</span>

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.

<span class="mw-page-title-main">WNT10B</span>

Protein Wnt-10b is a protein that in humans is encoded by the WNT10B gene.

<span class="mw-page-title-main">WNT9A</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-9a is a protein that in humans is encoded by the WNT9A gene.

<span class="mw-page-title-main">FRAT2</span> Protein-coding gene in the species Homo sapiens

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.

<span class="mw-page-title-main">UBE2R2</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.

<span class="mw-page-title-main">WNT5B</span>

Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene.

<span class="mw-page-title-main">CXXC5</span> Protein-coding gene in the species Homo sapiens

CXXC-type zinc finger protein 5 is a protein that is encoded by the CXXC5 gene in humans.

<span class="mw-page-title-main">WNT8B</span> Protein-coding gene in humans

Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000165879 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067199 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A (Mar 1997). "Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas". EMBO J. 16 (3): 441–50. doi:10.1093/emboj/16.3.441. PMC   1169648 . PMID   9034327.
  6. 1 2 "Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas".

Further reading


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.