Family with sequence similarity 19 member A4, C-C motif chemokine like

TAFA4
Identifiers
Aliases	TAFA4 , TAFA-4, family with sequence similarity 19 (chemokine (C-C motif)-like), member A4, family with sequence similarity 19 member A4, C-C motif chemokine like, TAFA chemokine like family member 4, FAM19A4
External IDs	OMIM: 617498 MGI: 2444563 HomoloGene: 18561 GeneCards: TAFA4
Gene location (Human)
Chr.	Chromosome 3 (human)
End	68,953,297 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	97,037,374 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; Left adrenal gland; ; prefrontal cortex; ; hypothalamus; ; Brodmann area 9; ; islet of Langerhans; ; substantia nigra; ; gallbladder; ; cingulate gyrus;
	Top expressed in
	cumulus cell; ; secondary oocyte; ; morula; ; spermatid; ; olfactory epithelium; ; iris; ; lateral geniculate nucleus; ; trigeminal ganglion; ; medial geniculate nucleus; ; medial dorsal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; receptor ligand activity ;
Cellular component	extracellular region ; extracellular space ;
Biological process	regulation of membrane potential ; regulation of sensory perception of pain ; phagocytosis ; regulation of signaling receptor activity ; superoxide anion generation ; macrophage chemotaxis ; signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	151647
	320701
	ENSG00000163377
	ENSMUSG00000046500
	Q96LR4
	Q7TPG5
	NM_001005527 ; NM_182522
	NM_177233
	NP_001005527 ; NP_872328 ; NP_001005527.1 ; NP_872328.1
	NP_796207
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Family with sequence similarity 19 member A4, C-C motif chemokine like is a protein that in humans is encoded by the FAM19A4 gene. ^[5]

Function

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011].

Related Research Articles

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Chemokine ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine, exodus-2, and secondary lymphoid-tissue chemokine (SLC). The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.

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Chemokine ligand (XCL1) is a small cytokine belonging to the C chemokine family that is also known as lymphotactin. Chemokines are known for their function in inflammatory and immunological responses. This family C chemokines differs in structure and function from most chemokines. There are only two chemokines in this family and what separated them from other chemokines is that they only have two cysteines; one N-terminal cysteine and one cysteine downstream. These both are called Lymphotactin, alpha and beta form, and claim special characteristics only found between the two. Lymphotactins can go through a reversible conformational change which changes its binding shifts.

Ras association domain-containing protein 1 is a protein that in humans is encoded by the RASSF1 gene.

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. Two ligands have been identified for this receptor: the chemokines ligand 19 (CCL19/ELC) and ligand 21 (CCL21).

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Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

Calsyntenin-1 is a protein that in humans is encoded by the CLSTN1 gene.

Dystrobrevin alpha is a protein that in humans is encoded by the DTNA gene.

Protein FAM19A1 is a protein that in humans is encoded by the FAM19A1 gene.

Family with Sequence Similarity 78-Member B (FAM78B) is a protein of unknown function in humans that is encoded by the FAM78B gene (1q24.1). It has orthologous genes and predicted proteins in vertebrates and several invertebrates, but not in arthropods. It has a nuclear localization signal in the protein sequence and a miRNA target region of the mRNA sequence.

Deltex E3 ubiquitin ligase 3L is a protein that in humans is encoded by the DTX3L gene.

Trafficking protein particle complex 9 is a protein that in humans is encoded by the TRAPPC9 gene.

C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene.

Sidekick cell adhesion molecule 1 is a protein that in humans is encoded by the SDK1 gene.

Disco interacting protein 2 homolog C is a protein that in humans is encoded by the DIP2C gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163377 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046500 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Family with sequence similarity 19 member A4, C-C motif chemokine like" . Retrieved 2017-12-09.

Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi: 10.1038/ajh.2009.190 . PMID 19851296.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi: 10.3892/ijmm_00000388 . PMID 20198315.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.
Wang W, Li T, Wang X, Yuan W, Cheng Y, Zhang H, Xu E, Zhang Y, Shi S, Ma D, Han W (2015). "FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages". Cell. Mol. Immunol. 12 (5): 615–24. doi:10.1038/cmi.2014.61. PMC 4579646 . PMID 25109685.
De Strooper LM, Meijer CJ, Berkhof J, Hesselink AT, Snijders PJ, Steenbergen RD, Heideman DA (2014). "Methylation analysis of the FAM19A4 gene in cervical scrapes is highly efficient in detecting cervical carcinomas and advanced CIN2/3 lesions". Cancer Prev Res (Phila). 7 (12): 1251–7. doi: 10.1158/1940-6207.CAPR-14-0237 . PMID 25281488.
Luttmer R, De Strooper LM, Berkhof J, Snijders PJ, Dijkstra MG, Uijterwaal MH, Steenbergen RD, van Kemenade FJ, Rozendaal L, Helmerhorst TJ, Verheijen RH, Ter Harmsel WA, Van Baal WM, Graziosi PG, Quint WG, Heideman DA, Meijer CJ (2016). "Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study)". Int. J. Cancer. 138 (4): 992–1002. doi: 10.1002/ijc.29824 . PMID 26317579.
De Strooper LM, Verhoef VM, Berkhof J, Hesselink AT, de Bruin HM, van Kemenade FJ, Bosgraaf RP, Bekkers RL, Massuger LF, Melchers WJ, Steenbergen RD, Snijders PJ, Meijer CJ, Heideman DA (2016). "Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women". Gynecol. Oncol. 141 (2): 341–347. doi:10.1016/j.ygyno.2016.02.012. PMC 4851217 . PMID 26921784.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163377 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046500 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Family with sequence similarity 19 member A4, C-C motif chemokine like" . Retrieved 2017-12-09.

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Family with sequence similarity 19 member A4, C-C motif chemokine like

Contents

Function

Related Research Articles

References

Further reading