Far upstream element-binding protein 1

FUBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J4W, 2KXH, 4LIJ
Identifiers
Aliases	FUBP1 , FBP, FUBP, hDH V, far upstream element binding protein 1
External IDs	OMIM: 603444 MGI: 1196294 HomoloGene: 48253 GeneCards: FUBP1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p31.1 Start 77,944,055 bp [1] End 77,979,110 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 H3|3 77.05 cM Start 151,916,059 bp [2] End 151,942,463 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon right uterine tube left lobe of thyroid gland right lobe of thyroid gland canal of the cervix lymph node tibial nerve anterior pituitary right lung Top expressed in maxillary prominence somite abdominal wall ganglionic eminence thymus hand primitive streak dermis yolk sac cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding single-stranded DNA binding DNA-binding transcription factor activity DNA binding RNA binding Cellular component nucleus nucleoplasm Biological process positive regulation of gene expression regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8880 51886 Ensembl ENSG00000162613 ENSMUSG00000028034 UniProt Q96AE4 Q91WJ8 RefSeq (mRNA) NM_001303433 NM_003902 NM_001376055 NM_001376056 NM_001376057 NM_057172 NM_001355366 NM_001355367 NM_001355368 NM_001355369 NM_001355370 NM_001355371 NM_001355372 NM_001355373 NM_001355374 RefSeq (protein) NP_001290362 NP_003893 NP_001362984 NP_001362985 NP_001362986 NP_476513 NP_001342295 NP_001342296 NP_001342297 NP_001342298 NP_001342299 NP_001342300 NP_001342301 NP_001342302 NP_001342303 Location (UCSC) Chr 1: 77.94 – 77.98 Mb Chr 3: 151.92 – 151.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene. ^{[5] [6]}

This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase. ^[6]

Interactions

Far upstream element-binding protein 1 has been shown to interact with MAPK14 ^[7] and SMN1. ^[8]

Clinical Significance

FUBP1 gene deletion forms part of the 1p/19q codeletion mutation seen in oligodendroglioma, a form of primary brain tumour. ^[9] CIC gene is also lost in the 1p/19q codeletion mutation.

References

1. GRCh38: Ensembl release 89: ENSG00000162613 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028034 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D (April 1994). "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif". Genes Dev. 8 (4): 465–80. doi: 10.1101/gad.8.4.465 . PMID   8125259.
6. "Entrez Gene: FUBP1 far upstream element (FUSE) binding protein 1".
7. Kim, Min Jung; Park Bum-Joon; Kang Young-Sun; Kim Hyoung June; Park Jae-Hyun; Kang Jung Woo; Lee Sang Won; Han Jung Min; Lee Han-Woong; Kim Sunghoon (July 2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. United States. 34 (3): 330–6. doi:10.1038/ng1182. ISSN   1061-4036. PMID   12819782. S2CID   41006480.
8. Williams, B Y; Hamilton S L; Sarkar H K (March 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. NETHERLANDS. 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. ISSN   0014-5793. PMID   10734235. S2CID   28330997.
9. Weller, Michael (8 December 2020). "EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood". Nature Reviews. Clinical Oncology. 18 (3): 170–186. doi:10.1038/s41571-020-00447-z. PMC   7904519 . PMID   33293629.

Further reading

• Williams BY, Hamilton SL, Sarkar HK (2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain". FEBS Lett. 470 (2): 207–10. doi:10.1016/S0014-5793(00)01320-X. PMID   10734235. S2CID   28330997.
• Liu J, He L, Collins I, et al. (2000). "The FBP interacting repressor targets TFIIH to inhibit activated transcription". Mol. Cell. 5 (2): 331–41. doi: 10.1016/S1097-2765(00)80428-1 . PMID   10882074.
• Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC   86300 . PMID   11003644.
• He L, Weber A, Levens D (2000). "Nuclear targeting determinants of the far upstream element binding protein, a c-myc transcription factor". Nucleic Acids Res. 28 (22): 4558–65. doi:10.1093/nar/28.22.4558. PMC   113884 . PMID   11071946.
• Vindigni A, Ochem A, Triolo G, Falaschi A (2001). "Identification of human DNA helicase V with the far upstream element-binding protein". Nucleic Acids Res. 29 (5): 1061–7. doi:10.1093/nar/29.5.1061. PMC   29729 . PMID   11222755.
• Liu J, Akoulitchev S, Weber A, et al. (2001). "Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum". Cell. 104 (3): 353–63. doi: 10.1016/S0092-8674(01)00223-9 . PMID   11239393.
• Braddock DT, Louis JM, Baber JL, et al. (2002). "Structure and dynamics of KH domains from FBP bound to single-stranded DNA". Nature. 415 (6875): 1051–6. Bibcode:2002Natur.415.1051B. doi:10.1038/4151051a. PMID   11875576. S2CID   4401103.
• Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC   186633 . PMID   12176931.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kim MJ, Park BJ, Kang YS, et al. (2003). "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation". Nat. Genet. 34 (3): 330–6. doi:10.1038/ng1182. PMID   12819782. S2CID   41006480.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kouzine F, Liu J, Sanford S, et al. (2004). "The dynamic response of upstream DNA to transcription-generated torsional stress". Nat. Struct. Mol. Biol. 11 (11): 1092–100. doi:10.1038/nsmb848. PMID   15502847. S2CID   28956216.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi: 10.1016/j.cell.2005.08.029 . hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070.
• Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Exp. Eye Res. 82 (6): 1046–52. doi:10.1016/j.exer.2005.09.016. PMID   16289162.
• Liu J, Kouzine F, Nie Z, et al. (2006). "The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression". EMBO J. 25 (10): 2119–30. doi:10.1038/sj.emboj.7601101. PMC   1462968 . PMID   16628215.
• Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate". J. Biol. Chem. 281 (24): 16193–6. doi: 10.1074/jbc.C600041200 . PMID   16672220.