Fat atypical cadherin 3

FAT3
Identifiers
Aliases	FAT3 , CDHF15, CDHR10, hFat3, FAT atypical cadherin 3
External IDs	OMIM: 612483 MGI: 2444314 HomoloGene: 82252 GeneCards: FAT3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	92,896,473 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	16,412,581 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; external globus pallidus; ; tibia; ; parietal lobe; ; entorhinal cortex; ; postcentral gyrus; ; Brodmann area 46; ; superior frontal gyrus;
	Top expressed in
	habenula; ; olfactory tubercle; ; median eminence; ; vas deferens; ; body of femur; ; mammillary body; ; globus pallidus; ; substantia nigra; ; superior colliculus; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding ;
Cellular component	integral component of membrane ; plasma membrane ; membrane ;
Biological process	homophilic cell adhesion via plasma membrane adhesion molecules ; multicellular organism development ; cell adhesion ; cell-cell adhesion ;
	Sources:Amigo / QuickGO
Orthologs
	120114
	270120
	ENSG00000165323
	ENSMUSG00000074505
	Q8TDW7
	Q8BNA6
	NM_001008781 ; NM_001367949 ; NM_001378141
	NM_001080814
	NP_001008781 ; NP_001354878 ; NP_001365070
	NP_001074283
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

FAT atypical cadherin 3 is a protein that in humans is encoded by the FAT3 gene.^[5]

Related Research Articles

Protocadherin-15 is a protein that in humans is encoded by the PCDH15 gene.

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.

Protocadherin FAT1 is a protein that in humans is encoded by the FAT1 gene.

Olfactory receptor 56A4 is a protein that in humans is encoded by the OR56A4 gene.

Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.

Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.

Protocadherin-7 is a protein that in humans is encoded by the PCDH7 gene.

Protein dachsous homolog 1, also known as protocadherin-16 (PCDH16) or cadherin-19 (CDH19) or cadherin-25 (CDH25) or fibroblast cadherin-1 (FIB1), is a protein that in humans is encoded by the DCHS1 gene.

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.

Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.

Cadherin 9 is a protein that in humans is encoded by the CDH9 gene.

Zing finger protein 644 (ZNF644) also known as zinc finger motif enhancer-binding protein 2 (Zep-2) is a protein that in humans is encoded by the ZNF644 gene.

The E3 ubiquitin-protein ligase Hakai (HAKAI) also known as Casitas B-lineage lymphoma-transforming sequence-like protein 1 (CBLL1) is an enzyme that in humans is encoded by the CBLL1 gene. This gene encodes an E3 ubiquitin ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation.

YTH domain containing 2 is a protein that in humans is encoded by the YTHDC2 gene.

Unc-93 homolog A is a protein that in humans is encoded by the UNC93A gene.

Nanos homolog 1 (Drosophila) is a protein that in humans is encoded by the NANOS1 gene.

Cadherin related family member 3 (CDHR3), also known as CDH28 or its abbreviation CDHR3, is a protein that in humans is encoded by the CDHR3 gene. The protein is predominately expressed in respiratory epithelium and the first notion of its clinical implications was from the discovery that genetic variation of CDHR3 is strongly associated to early severe asthma exacerbations in children. Subsequent studies have suggested that CDHR3 is a receptor for a subtype of rhinovirus.

Major facilitator superfamily domain-containing protein 9 is a protein that in humans is encoded by the MFSD9 gene. It is a potential solute carrier, and called atypical solute carrier since it is not named according to the SLC nomenclature. It is expressed both in central and peripheral organs.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165323 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074505 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: FAT atypical cadherin 3".

Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT (September 2011). "Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling". The Journal of Cell Biology. 194 (5): 737–50. doi:10.1083/jcb.201107021. PMC 3171123 . PMID 21875946.
Zheng JS, Arnett DK, Lee YC, Shen J, Parnell LD, Smith CE, Richardson K, Li D, Borecki IB, Ordovás JM, Lai CQ (2013). "Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits". PLOS ONE. 8 (10): e77442. Bibcode:2013PLoSO...877442Z. doi: 10.1371/journal.pone.0077442 . PMC 3810463 . PMID 24204828.
Mitsui K, Nakajima D, Ohara O, Nakayama M (February 2002). "Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs". Biochemical and Biophysical Research Communications. 290 (4): 1260–6. doi:10.1006/bbrc.2002.6338. PMID 11811999.
Wu Q (April 2005). "Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes". Genetics. 169 (4): 2179–88. doi:10.1534/genetics.104.037606. PMC 1449604 . PMID 15744052.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000165323 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074505 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FAT atypical cadherin 3".

[1]

[2]

[3]

[4]

[5]

Fat atypical cadherin 3

Related Research Articles

References

Further reading