Fat atypical cadherin 3

FAT3
Identifiers
Aliases	FAT3 , CDHF15, CDHR10, hFat3, FAT atypical cadherin 3
External IDs	OMIM: 612483; MGI: 2444314; HomoloGene: 82252; GeneCards: FAT3; OMA:FAT3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q14.3 Start 92,224,818 bp [1] End 92,896,473 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A2 Start 15,821,485 bp [2] End 16,412,581 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Brodmann area 23 middle temporal gyrus endothelial cell external globus pallidus tibia parietal lobe entorhinal cortex lateral nuclear group of thalamus postcentral gyrus Top expressed in habenula olfactory tubercle median eminence vas deferens body of femur mammillary body globus pallidus substantia nigra superior colliculus lateral septal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane membrane Biological process homophilic cell adhesion via plasma membrane adhesion molecules multicellular organism development cell adhesion cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 120114 270120 Ensembl ENSG00000165323 ENSMUSG00000074505 UniProt Q8TDW7 Q8BNA6 RefSeq (mRNA) NM_001008781 NM_001367949 NM_001378141 NM_001080814 RefSeq (protein) NP_001008781 NP_001354878 NP_001365070 NP_001074283 Location (UCSC) Chr 11: 92.22 – 92.9 Mb Chr 9: 15.82 – 16.41 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FAT atypical cadherin 3 is a protein that in humans is encoded by the FAT3 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000165323 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074505 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FAT atypical cadherin 3".

Further reading

• Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT (September 2011). "Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling". The Journal of Cell Biology. 194 (5): 737–50. doi:10.1083/jcb.201107021. PMC   3171123 . PMID   21875946.
• Zheng JS, Arnett DK, Lee YC, Shen J, Parnell LD, Smith CE, Richardson K, Li D, Borecki IB, Ordovás JM, Lai CQ (2013). "Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits". PLOS ONE. 8 (10) e77442. Bibcode:2013PLoSO...877442Z. doi: 10.1371/journal.pone.0077442 . PMC   3810463 . PMID   24204828.
• Mitsui K, Nakajima D, Ohara O, Nakayama M (February 2002). "Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs". Biochemical and Biophysical Research Communications. 290 (4): 1260–6. doi:10.1006/bbrc.2002.6338. PMID   11811999.
• Wu Q (April 2005). "Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes". Genetics. 169 (4): 2179–88. doi:10.1534/genetics.104.037606. PMC   1449604 . PMID   15744052.