State Road 100 is a 153-mile-long (246 km) east–west highway serving northeast Florida. Its western terminus is at the Georgia-Florida border four miles (6.4 km) north of Avoca, Florida ; its eastern terminus is an intersection with Shore Scenic Highway in Flagler Beach. The portion west of Lake City is only signed as portions of US 41 and US 129, both of which run north–south.
State Road 145 runs north from US 90 and State Road 53 in Madison to the Georgia border, where it becomes State Route 31. It is also a short route in Fort Walton Beach between US 98 and State Road 85.
State Road 25 is a state highway in the U.S. state of Florida. It is mainly signed as U.S. Highways:
U.S. Highway 1 (US 1) in Florida runs 545 miles (877 km) along the state's east coast from Key West to its crossing of the St. Marys River into Georgia north of Boulogne and south of Folkston. US 1 was designated through Florida when the U.S. Numbered Highway System was established in 1926. With the exception of Monroe County, the highway runs through the easternmost tier of counties in the state, connecting numerous towns and cities along its route, including nine county seats. The road is maintained by the Florida Department of Transportation (FDOT).
State Road 48 (SR 48) was an east–west state highway that ran from U.S. Highway 41 in Floral City, Florida, to Florida State Road 19 in Howey-in-the-Hills, Florida. In the last years of the route's existence, it was a 2.167 miles (3.487 km) state road in Bushnell, Florida, which ran from Interstate 75 (I-75) at exit 314 to U.S. Highway 301 (US 301). Today, all segments are designated County Road 48 (CR 48), where they are under county maintenance. Segments in Sumter County are part of the Scenic Sumter Heritage Byway.
State Road 173, locally known as Blue Angel Parkway, is a major thoroughfare in the Pensacola, Florida metropolitan area. SR 173 has its southern terminus at the western entrance to NAS Pensacola, and runs south–north through West Pensacola to its northern terminus at State Road 297.
State Route 21 (SR 21) is a 279-mile (449 km) state highway that extends from the Florida state line, near Atmore in Escambia County to Piedmont in Calhoun County. The route travels almost the entire length of the state from the northeast to the southwest. It is the longest signed state route in Alabama.
U.S. Route 29 (US 29), internally designated by the Alabama Department of Transportation (ALDOT) as State Route 15 (SR 15), is a southwest–northeast state highway across the southeastern part of the U.S. state of Alabama. US 29 and SR 15 traverse Alabama in a general northeast–southwest slope. It has never been a major route in the state; its significance was completely overshadowed with the completion of Interstate 65 (I-65) and I-85 during the 1970s. Today, US 29 and SR 15 serve primarily to connect numerous smaller towns and cities in the southwest, south-central, and eastern parts of Alabama.
State Road 4 is a 43.705-mile-long (70.336 km) two-lane state highway in Escambia, Santa Rosa, and Okaloosa counties in the western corner of the Florida Panhandle. It is signed east–west, but the road is slightly diagonal. The road runs from Century near the Alabama state line at an intersection with U.S. Highway 29 (US 29), to the farming community of Milligan at an intersection with US 90.
U.S. Highway 17 (US 17) in Florida is a north–south United States Numbered Highway that runs 317 miles (510 km) from the Punta Gorda, Florida Metropolitan Statistical Area northeast to the Jacksonville metropolitan area.
U.S. Highway 19 (US 19) runs about 262 miles (422 km) along Florida's west coast from an interchange with US 41 in Memphis, south of Tampa, and continues to the Georgia border north of Monticello.
U.S. Highway 29 (US 29) in the state of Florida is the westernmost north–south United States Numbered Highway in the state. It runs 43.6 miles (70.2 km) from downtown Pensacola north to the Alabama state line entirely within Escambia County. US 29 runs as a four-lane highway through much of the Florida Panhandle, becoming six lanes through and near several towns. The highway's hidden state road designation is entirely State Road 95 (SR 95).
U.S. Route 90 (US 90) in the state of Florida is the northernmost east–west United States Numbered Highway in the state. US 90 passes through the county seats of all 15 counties on its course in Florida, and it is also the road upon which many of the county courthouses are located. It is never more than six miles (9.7 km) from Interstate 10 (I-10) throughout the state. It runs as a two-lane highway through most of the sparsely populated inland areas of the Florida Panhandle, widening to four lanes through and near several towns. The speed limit is 55 mph (89 km/h) for all rural points west of Monticello, and it is 60 mph (97 km/h) on all rural points from where it enters Madison County as far as Glen St. Mary.
U.S. Route 301 in Florida runs from the Sarasota-Bradenton-Venice, Florida Metropolitan Statistical Area northeast to the Greater Jacksonville Metropolitan Area. The road is a spur of U.S. Route 1, which it intersects in Callahan.
State Road 289, known locally as North 9th Avenue, is a north–south major thoroughfare in Pensacola, Florida.
State Road 298, known locally as Lillian Highway, is a mostly east–west thoroughfare in Pensacola, Florida. It runs from its intersection with U.S. Highway 98 and Dog Track Road, skirting Perdido Bay on its way east to its terminus at the West Pensacola spur of SR 295. SR 298 passes under the mainline of SR 295 without an interchange. It serves as a major route through the communities of Myrtle Grove and West Pensacola.
State Road 329 (SR 329) was a short state highway traveling south and north through Gainesville, Florida. It comprised Main Street through Gainesville. The full length of the road extended from SR 331 to County Road 232 (CR 232). In the 1970s, the northern portion of the road, most of North Main Street, became County Road 329 (CR 329) while South Main Street was relinquished by the Florida Department of Transportation (FDOT) to the city. A small portion of the former state road in Gainesville is still maintained by the state as a portion of SR 20.
The Ormond Scenic Loop and Trail is a series of scenic state and county highways in Volusia County, Florida. CR 2002 is the northern leg of the trail. CR 4011(Old Dixie Highway and North Beach Street) is the western leg, with a spur onto Pine Tree Drive. SR 40(East Granada Boulevard) is the southern leg of the trail. CR 2803(John Anderson Drive) is the central leg of the trail, and SR A1A is the eastern leg of the trail. Florida Scenic Highway, designated this route on July 9, 2007.
State Road 89 is a north–south highway in the state of Florida that extends from U.S. Route 90 to the Alabama state line where it becomes County Road 55. All of SR 89 is contained within Santa Rosa County, and most of the road is a two-lane undivided highway, except between Milton and Point Baker, where it is a four-lane divided highway.
State Road 99 is a 2.56-mile-long (4.12 km) north–south highway running along Belulah Avenue in unincorporated Escambia County, Florida. It is the westernmost north–south two-digit highway in Florida. The southern terminus is at the intersection with Mobile Highway and Belulah Avenue, while the northern terminus is at the intersection of Isaacs Lane and Belulah Avenue.
CR 95A in Molino 
US 29 in Molino
CR 99A in Walnut Hill 
SR 21 in Atmore, AL 
