Fluloprazolam

Not to be confused with Flualprazolam.

Fluloprazolam

Identifiers
IUPAC name (2Z)-6-(2-Fluorophenyl)-2-[(4-methylpiperazin-1-yl)methylidene]-8-nitro-4H-imidazo[1,2-a][1,4]benzodiazepin-1-one
CAS Number	63146-74-7
PubChem CID	12371485
ChemSpider	34243184
ChEMBL	ChEMBL3249357
Chemical and physical data
Formula	C23H21FN6O3
Molar mass	448.458 g·mol−1
3D model (JSmol)	Interactive image
Melting point	303–306 °C (577–583 °F) [1]
SMILES CN1CCN(CC1)/C=C\2/C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5F
InChI InChI=InChI=1S/C23H21FN6O3/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24/h2-7,12,14H,8-11,13H2,1H3/b19-14- Key:JYMHWJZLSYFHJD-RGEXLXHISA-N

Fluloprazolam (also known as fluoprazolam) is a benzodiazepine derivative which has been sold online as a designer drug. It is an analog of loprazolam with the chlorine atom on the phenyl group being replaced by a fluorine atom.

History

Fluloprazolam was first described in 1977 by Ager et al. ^[1]

Pharmacology

Fluloprazolam is expected to have similar pharmacological properties as loprazolam. Its general level of activity has been described as "very high" alongside that of loprazolam. ^{[1] [a]} However, fluloprazolam’s dosing range and potency relative to other benzodiazepines has not been described in scientific literature.

Other pharmacological data on fluloprazolam is extremely limited. Little is known about its exact receptor targets, metabolism, and potential toxicity.

References

1. Ager IR, Danswan GW, Harrison DR, Kay DP, Kennewell PD, Taylor JB (August 1977). "Central nervous system activity of a novel class of annelated 1,4-benzodiazepines, aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-ones". Journal of Medicinal Chemistry. 20 (8): 1035–1041. doi:10.1021/jm00218a009. PMID   19630.

Notes

1. As compared to their parent compounds, which have no halogen on the phenyl group, and have a chlorine atom instead of a nitro group on the benzene ring; IUPAC name (2Z)-6-phenyl-2-[(4-methylpiperazin-1-yl)methylidene]-8-chloro-4H-imidazo[1,2-a][1,4]benzodiazepin-1-one.

See also

• Flualprazolam
• Loprazolam
• List of benzodiazepines