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Formulation is a term used in various senses in various applications, both the material and the abstract or formal. Its fundamental meaning is the putting together of components in appropriate relationships or structures, according to a formula. Etymologically formula is the diminutive of the Latin forma, meaning shape. In that sense a formulation is created according to the standard for the product. [1]
Disciplines in which one might use the word formulation in the abstract sense include logic, mathematics, linguistics, legal theory, and computer science. For details, see the related articles.
In more material senses the concept of formulation appears in the physical sciences, such as physics, chemistry, and biology. It also is ubiquitous in industry, engineering and medicine, especially pharmaceutics.
In pharmacy, a formulation is a mixture or a structure such as a capsule, tablet, or an emulsion, prepared according to a specific procedure (called a "formula"). Formulations are a very important aspect of creating medicines, since they are essential to ensuring that the active part of the drug is delivered to the correct part of the body, in the right concentration, and at the right rate (not too fast and not too slowly). A good example is a drug delivery system that exploits supersaturation. They also need to have an acceptable taste (in the case of pills, tablets or syrups), last long enough in storage still to be safe and effective when used, and be sufficiently stable both physically and chemically to be transported from where they are manufactured to the eventual consumer. Competently designed formulations for particular applications are safer, more effective, and more economical than any of their components used singly.
Formulations are commercially produced for drugs, cosmetics, coatings, dyes, alloys, cleaning agents, foods, lubricants, fuels, fertilisers, pesticides and many others.
Components (also called ingredients), when mixed according to a formula, create a formulation.
Some components impart specific properties to the formulation when it is put into use. For example, certain components (polymers) are used in paint formulations to achieve deforming or levelling properties. [2] Some components of a formulation may only be active in particular applications.
A formulation may be created for any of the following purposes:
Paint is any pigmented liquid, liquefiable, or solid mastic composition that, after application to a substrate in a thin layer, converts to a solid film. It is most commonly used to protect, color and primer, or provide texture. Paint can be made in many colors—and in many different types. Paint is typically stored, sold, and applied as a liquid, but most types dry into a solid. Most paints are either oil-based or water-based and each has distinct characteristics. For one, it is illegal in most municipalities to discard oil-based paint down household drains or sewers. Clean-up solvents are also different for water-based paint than they are for oil-based paint. Water-based paints and oil-based paints will cure differently based on the outside ambient temperature of the object being painted. Usually, the object being painted must be over 10 °C (50 °F), although some manufacturers of external paints/primers claim they can be applied when temperatures are as low as 2 °C (35 °F).
Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone. PVP is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties.
A tablet is a pharmaceutical oral dosage form or solid unit dosage form. Tablets may be defined as the solid unit dosage form of medication with suitable excipients. It comprises a mixture of active substances and excipients, usually in powder form, that are pressed or compacted into a solid dose. The main advantages of tablets are to ensure a consistent dose of medicine that is easy to consume.
In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation.
A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. Many topical medications are epicutaneous, meaning that they are applied directly to the skin. Topical medications may also be inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a tooth. The word topical derives from Greek τοπικόςtopikos, "of a place".
Paint stripper, or paint remover, is a chemical product designed to remove paint, finishes, and coatings, while also cleaning the underlying surface.
An excipient is a substance formulated alongside the active ingredient of a medication, included for the purpose of long-term stabilization, bulking up solid formulations that contain potent active ingredients in small amounts, or to confer a therapeutic enhancement on the active ingredient in the final dosage form, such as facilitating drug absorption, reducing viscosity, or enhancing solubility. Excipients can also be useful in the manufacturing process, to aid in the handling of the active substance concerns such as by facilitating powder flowability or non-stick properties, in addition to aiding in vitro stability such as prevention of denaturation or aggregation over the expected shelf life. The selection of appropriate excipients also depends upon the route of administration and the dosage form, as well as the active ingredient and other factors. A comprehensive classification system based on structure-property-application relationships has been proposed for excipients used in parenteral medications.
An active ingredient is any ingredient that provides biologically active or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body of humans or animals.
Magnesium stearate is the chemical compound with the formula Mg(C
18H
35O
2)
2. It is a soap, consisting of salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate is a white, water-insoluble powder. Its applications exploit its softness, insolubility in many solvents, and low toxicity. It is used as a release agent and as a component or lubricant in the production of pharmaceuticals and cosmetics.
Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
Pharmaceutical formulation, in pharmaceutics, is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product. The word formulation is often used in a way that includes dosage form.
Modified-release dosage is a mechanism that delivers a drug with a delay after its administration or for a prolonged period of time or to a specific target in the body.
Agricultural spray adjuvants are part of integrated pest management, and during pesticide application are used to enhance the effectiveness of pesticides, herbicides, insecticides, fungicides and other agents that control or eliminate unwanted pests. As with medical adjuvants, agricultural spray adjuvants are not themselves active in controlling or killing pests. Instead, these additives modify some property of the spray solution, which improves the ability of the pesticide to penetrate, target or protect the target organism. Among the typical types of ingredients used are surfactants, emulsifiers, oils and salts. Each of these ingredients, and others, modifies the spray solution itself to improve such properties as spreading, penetration, droplet size or other characteristics.
Hydroxyethyl cellulose is a gelling and thickening agent derived from cellulose. It is widely used in cosmetics, cleaning solutions, and other household products. Hydroxyethyl cellulose and methyl cellulose are frequently used with hydrophobic drugs in capsule formulations, to improve the drugs' dissolution in the gastrointestinal fluids. This process is known as hydrophilization.
Pharmaceutical manufacturing is the process of industrial-scale synthesis of pharmaceutical drugs as part of the pharmaceutical industry. The process of drug manufacturing can be broken down into a series of unit operations, such as milling, granulation, coating, tablet pressing, and others.
Tableting is a method of pressing medicine or candy into tablets. Confectionery manufacture shares many similarities with pharmaceutical production.
Deformulation refers to a set of analytical procedures used to separate and identify individual components of a formulated chemical substance. Deformulation applies methods of analytical chemistry and is often used to obtain competitive intelligence about chemical products. Deformulation is related to reverse engineering; however, the latter concept is most closely associated with procedures used to discover working principles of a device or a designed system through examination and disassembly of its structure. The term, reverse engineering, has become specifically and almost exclusively linked to the field of software engineering; whereas, deformulation is a term more applicable to the field of chemical manufacturing. Deformulation of a multicomponent chemical mixture may occur in several contexts, including the investigation of causes of chemical product failure, competitive benchmarking, legal inquiry to obtain evidence of patent infringement, or new product research and development. Depending upon this context and upon the level of information sought, the requirements of analyses for deformulation may differ. Deformulation processes typically require the application of several analytical methods, and the selection of methods is dependent upon the degree of confidence required in the results. Methods of deformulation also have similarity to methods of forensic chemistry in which analytical procedures may be applied to discover the causes of material failure or to resolve a legal question.
Copper naphthenate is the copper salt of naphthenic acid. Naphthenic acid is a term commonly used in the petroleum industry to collectively refer to all of the carboxylic acids naturally occurring in crude oil. Naphthenic acids are primarily cycloaliphatic carboxylic acids with 10 to 24 or more carbons, although substantial quantities of non-cyclic, aromatic and heteroatom- containing carboxylic acids are also present. Copper naphthenate is most widely used in wood preservation and for protecting other cellulosic materials such as textiles and cordage from damage by decay fungi and insects. Other metal naphthenates are used as paint driers, rubber adhesion promoters, lubricant additives, and catalysts where oil solubility is required.
Speciality chemicals are particular chemical products which provide a wide variety of effects on which many other industry sectors rely. Some of the categories of speciality chemicals are adhesives, agrichemicals, cleaning materials, colors, cosmetic additives, construction chemicals, elastomers, flavors, food additives, fragrances, industrial gases, lubricants, paints, polymers, surfactants, and textile auxiliaries. Other industrial sectors such as automotive, aerospace, food, cosmetics, agriculture, manufacturing, and textiles are highly dependent on such products.
2-Octanol is an organic compound with the chemical formula CH3CH(OH)(CH2)5CH3. It is a colorless oily liquid that is poorly soluble in water but soluble in most organic solvents. 2-Octanol is classified fatty alcohol. A secondary alcohol, it is chiral.