Francine Laden | |
---|---|
Alma mater | Harvard University |
Scientific career | |
Fields | Environmental epidemiology Chronic diseases |
Institutions | Harvard T.H. Chan School of Public Health |
Thesis | Environmental risk factors and breast cancer (1998) |
Website | www |
Francine Laden is an American epidemiologist who is Professor of Environmental Epidemiology at the Harvard T.H. Chan School of Public Health. [1] [2] Her research has investigated the environmental epidemiology of chronic disease. She serves as co-director of the Harvard University and Boston University center for research on environmental and social stressors in housing across the life course. Laden has also served on the United States Environmental Protection Agency advisory board. [3]
Laden was an undergraduate at Princeton University and graduate student at the Harvard T.H. Chan School of Public Health. [4] Her doctoral research looked for environmental risk factors for breast cancer. [5] At the time, the incidence of breast cancer was rising in the United States, and Laden wondered whether specific exposures/environments made people more susceptible to the disease. Whilst her results were inconclusive, they did not indicate environmental risk factors played a considerable role in the disease. [6] She went on to show that long-term rotating night shift work was associated with a higher incidence of breast cancer, and that women who did shiftwork younger were more at risk. [7] In 2007, the World Health Organization classified night shift work as a probable carcinogen. [8]
Laden studies the epidemiology of chronic disease. [9] She has studied how air pollution, [10] [11] persistent organic pollutants and second hand smoke can impact human health, and how risk is distributed across America. [12] [13] Laden has studied the environmental risk factors of various cancers, including breast cancer, lung cancer and non-Hodgkin's lymphoma. [14] She has studied how diesel exhaust exposure impacts lung cancer mortality in America's trucking industry. Alongside cancer, Laden showed that exposure to particulate matter was associated with high levels of anxiety. [15]
By combining satellite imagery (the normalized difference vegetation index), physical examinations and cognitive tests, Laden research showed that access to urban green space could improve processing speed, attention span and cognitive function. [16] She showed that a lack of access to green space was associated to with higher incidences of depression. [16] By combining the imagery with medical records, she hypothesised that women who live in areas with high levels of outdoor lighting are at greater risk for breast cancer that those in areas with lower light levels. [17] She hypothesised that this was due to a reduction in melatonin, which disrupts circadian rhythms. [17]
Almost half of American adults suffer from hypertension. [18] Whilst diet, obesity and level of physical activity contribute to risk, it was unclear how environmental exposures impact risk. She based her research on young people enrolled on the Growing Up Today Study, and included data on chemical stressors, physical stressors and features of the built environment. Her research has shown that exposure to aircraft noise (i.e. living near an airport) increased the risk of hypertension. [19]
In 2021 Laden was made President of the International Society for Environmental Epidemiology. [20] Under her leadership, the International Society for Environmental Epidemiology developed its North American community. [21]
Environmental health is the branch of public health concerned with all aspects of the natural and built environment affecting human health. In order to effectively control factors that may affect health, the requirements that must be met in order to create a healthy environment must be determined. The major sub-disciplines of environmental health are environmental science, toxicology, environmental epidemiology, and environmental and occupational medicine.
Low birth weight (LBW) is defined by the World Health Organization as a birth weight of an infant of 2,499 g or less, regardless of gestational age. Infants born with LBW have added health risks which require close management, often in a neonatal intensive care unit (NICU). They are also at increased risk for long-term health conditions which require follow-up over time.
The Nurses' Health Study is a series of prospective studies that examine epidemiology and the long-term effects of nutrition, hormones, environment, and nurses' work-life on health and disease development. The studies have been among the largest investigations into risk factors for major chronic diseases ever conducted. The Nurses' Health Studies have led to many insights on health and well-being, including cancer prevention, cardiovascular disease, and type 2 diabetes. They have included clinicians, epidemiologists, and statisticians at the Channing Laboratory, Harvard Medical School, Harvard School of Public Health, and several Harvard-affiliated hospitals, including Brigham and Women's Hospital, Dana–Farber Cancer Institute, Children's Hospital Boston, and Beth Israel Deaconess Medical Center.
Disease burden is the impact of a health problem as measured by financial cost, mortality, morbidity, or other indicators. It is often quantified in terms of quality-adjusted life years (QALYs) or disability-adjusted life years (DALYs). Both of these metrics quantify the number of years lost due to disability (YLDs), sometimes also known as years lost due to disease or years lived with disability/disease. One DALY can be thought of as one year of healthy life lost, and the overall disease burden can be thought of as a measure of the gap between current health status and the ideal health status. According to an article published in The Lancet in June 2015, low back pain and major depressive disorder were among the top ten causes of YLDs and were the cause of more health loss than diabetes, chronic obstructive pulmonary disease, and asthma combined. The study based on data from 188 countries, considered to be the largest and most detailed analysis to quantify levels, patterns, and trends in ill health and disability, concluded that "the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013." The environmental burden of disease is defined as the number of DALYs that can be attributed to environmental factors. Similarly, the work-related burden of disease is defined as the number of deaths and DALYs that can be attributed to occupational risk factors to human health. These measures allow for comparison of disease burdens, and have also been used to forecast the possible impacts of health interventions. By 2014 DALYs per head were "40% higher in low-income and middle-income regions."
C. Arden Pope III is an American professor of economics at Brigham Young University and one of the world's foremost experts in environmental science. He received his B.S. from Brigham Young University (BYU) in 1978 and his Ph.D. in economics and statistics from Iowa State University in 1981. Although his research includes many papers on topics in the fields in which he was trained—environmental economics, resource economics, and agricultural economics—he is better known for his cross-disciplinary work in environmental epidemiology and public health. He is world-renowned for his seminal work on the effects of particulate air pollution on mortality and health. His articles have helped establish the connection between air pollution and health problems, including cancer, cardiovascular, and pulmonary disease. These research findings have influenced environmental policy in the United States and Europe, contributing to the establishment of emission standards for particulate matter pollution.
Air pollution is the contamination of air due to the presence of substances in the atmosphere that are harmful to the health of humans and other living beings, or cause damage to the climate or to materials. It is also the contamination of indoor or outdoor surrounding either by chemical activities, physical or biological agents that alters the natural features of the atmosphere. There are many different types of air pollutants, such as gases, particulates, and biological molecules. Air pollution can cause diseases, allergies, and even death to humans; it can also cause harm to other living organisms such as animals and food crops, and may damage the natural environment or built environment. Air pollution can be caused by both human activities and natural phenomena.
Risk factors for breast cancer may be divided into preventable and non-preventable. Their study belongs in the field of epidemiology. Breast cancer, like other forms of cancer, can result from multiple environmental and hereditary risk factors. The term "environmental", as used by cancer researchers, means any risk factor that is not genetically inherited.
Air pollution is the introduction of chemicals, particulate matter, or biological materials into the atmosphere, causing harm or discomfort to humans or other living organisms, or damaging ecosystems. Air pollution can cause health problems including, but not limited to, infections, behavioral changes, cancer, organ failure, and premature death. These health effects are not equally distributed across the U.S population; there are demographic disparities by race, ethnicity, socioeconomic status, and education. Air pollution can derive from natural sources, or anthropogenic sources. Anthropogenic air pollution has affected the United States since the beginning of the Industrial Revolution.
Light in school buildings traditionally is from a combination of daylight and electric light to illuminate learning spaces, hallways, cafeterias, offices and other interior areas. Light fixtures currently in use usually provide students and teachers with satisfactory visual performance, i.e., the ability to read a book, have lunch, or play basketball in a gymnasium. However, classroom lighting may also affect students' circadian systems, which may in turn affect test scores, attendance and behavior.
Particulates – also known as atmospheric aerosol particles, atmospheric particulate matter, particulate matter (PM) or suspended particulate matter (SPM) – are microscopic particles of solid or liquid matter suspended in the air. The term aerosol commonly refers to the particulate/air mixture, as opposed to the particulate matter alone. Sources of particulate matter can be natural or anthropogenic. They have impacts on climate and precipitation that adversely affect human health, in ways additional to direct inhalation.
In the United States about 10% of the population, 33 million people, live within 900 meters of a high traffic road High-traffic roads are commonly identified as being host to more than 50,000 vehicles per day, which is a source of toxic vehicle pollutants. Previous studies have found correlations between exposure to vehicle pollutants and certain diseases such as asthma, lung and heart disease, and cancer among others. Car pollutants include carbon monoxide, nitrogen oxides, particulate matter, and toxic air pollutants While these pollutants affect the general health of populations, they are known to also have specific adverse effects on expectant mothers and their fetuses. The purpose of this article is to outline how vehicular pollutants affect the health of expectant mothers and the adverse health effects these exposure have on the adult.
Occupational cancer is cancer caused by occupational hazards. Several cancers have been directly tied to occupational hazards, including chimney sweeps' carcinoma, mesothelioma, and others.
Nishi Chaturvedi is a Professor of Clinical Epidemiology at University College London. Her research considers how ethnicity and lifestyle impact people's risk factors for disease. During the COVID-19 pandemic, Chaturvedi explained that the increased mortality rate for people from black and minority ethnic backgrounds was due to societal inequality and how this intersects with healthcare.
Stephanie J. London is an American epidemiologist and physician-scientist specializing in environmental health, respiratory diseases, and genetic susceptibility. She is the deputy chief of the epidemiology branch at the National Institute of Environmental Health Sciences.
The Harvard "Six Cities" study was a major epidemiological study of over 8,000 adults in six American cities that helped to establish the connection between fine-particulate air pollution and reduced life expectancy. Widely acknowledged as a landmark piece of public health research, it was initiated by Benjamin G. Ferris, Jr at Harvard School of Public Health and carried out by Harvard's Douglas Dockery, C. Arden Pope of Brigham Young University, Ferris himself, Frank E. Speizer, and four other collaborators, and published in the New England Journal of Medicine in 1993. Following a lawsuit by The American Lung Association, the study, and its various follow-ups, led to a tightening of pollution standards by the US Environmental Protection Agency. This prompted an intense backlash from industry groups in the late 1990s, culminating in a Supreme Court case, in what Science magazine termed "the biggest environmental fight of the decade".
Biological inequity, also known as biological inequality, refers to “systematic, unfair, and avoidable stress-related biological differences which increase risk of disease, observed between social groups of a population”. The term developed by Centric Lab aims to unify societal factors with the biological underpinnings of health inequities – the unfair and avoidable differences in health status and risks between social groups of a population - such that these inequalities can be investigated in a holistic manner.
Frank Erwin Speizer is an American physician and epidemiologist, currently Professor of Environmental Health and Environmental Science at Harvard T.H. Chan School of Public Health, and Edward H. Kass Distinguished Professor of Medicine at Brigham and Women's Hospital, Harvard Medical School. He is best known for his work on two major epidemiological cohort studies: the Nurses' Health Study, which explored women's illnesses and health risk factors, and the Harvard Six Cities study, which definitively linked air pollution to higher death rates in urban areas.
Patricia Coogan is Senior Epidemiologist at the Slone Epidemiology Center and a Boston University School of Public Health (BUSPH) Research Professor in the Department of Epidemiology. She is a co-nvestigator for the Black Women’s Health Study (BWHS), a prospective study at the Slone Epidemiology Center.
Susan Hankinson is an American cancer researcher who is the Distinguished Professor of Epidemiology at the University of Massachusetts Amherst. Her research considers cancer epidemiology and the etiology of breast cancer. Her work has demonstrated the relationship between hormones and breast cancer risk. In 2023, she was awarded the American Association for Cancer Research Award for Research Excellence in Cancer Epidemiology and Prevention.
A. Heather Eliassen is an American public health researcher who is a Professor of Epidemiology at the Harvard T.H. Chan School of Public Health. Her research considers the epidemiology of breast cancer and the identification of modifiable risk factors to reduce breast cancer risk.