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Molecular imaging is a field of medical imaging that focuses on imaging molecules of medical interest within living patients. This is in contrast to conventional methods for obtaining molecular information from preserved tissue samples, such as histology. Molecules of interest may be either ones produced naturally by the body, or synthetic molecules produced in a laboratory and injected into a patient by a doctor. The most common example of molecular imaging used clinically today is to inject a contrast agent into a patient's bloodstream and to use an imaging modality to track its movement in the body. Molecular imaging originated from the field of radiology from a need to better understand fundamental molecular processes inside organisms in a noninvasive manner.
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Stefan Walter Hell is a Romanian-German physicist and one of the directors of the Max Planck Institute for Multidisciplinary Sciences in Göttingen, and of the Max Planck Institute for Medical Research in Heidelberg, both of which are in Germany. He received the Nobel Prize in Chemistry in 2014 "for the development of super-resolved fluorescence microscopy", together with Eric Betzig and William Moerner.
The Max Planck Institute for Medical Research in Heidelberg, Germany, is a facility of the Max Planck Society for basic medical research. Since its foundation, six Nobel Prize laureates worked at the Institute: Otto Fritz Meyerhof (Physiology), Richard Kuhn (Chemistry), Walther Bothe (Physics), André Michel Lwoff, Rudolf Mößbauer (Physics), Bert Sakmann and Stefan W. Hell (Chemistry).
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Winfried Denk is a German physicist. He built the first two-photon microscope while he was a graduate student in Watt W. Webb's lab at Cornell University, in 1989.
Christoph Cremer is a German physicist and emeritus at the Ruprecht-Karls-University Heidelberg, former honorary professor at the University of Mainz and was a former group leader at Institute of Molecular Biology (IMB) at the Johannes Gutenberg University of Mainz, Germany, who has successfully overcome the conventional limit of resolution that applies to light based investigations by a range of different methods. In the meantime, according to his own statement, Christoph Cremer is a member of the Max Planck Institute for Chemistry and the Max Planck Institute for Polymer Research.
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Robert Eric Betzig is an American physicist who works as a professor of physics and professor of molecular and cell biology at the University of California, Berkeley. He is also a senior fellow at the Janelia Farm Research Campus in Ashburn, Virginia.
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Ilaria Testa is an Italian-born scientist who is a Fellow at the SciLifeLab in Stockholm and an Associate Professor at the Department of Applied Physics at the School of Engineering Science at the KTH Royal Institute of Technology. She has made major contributions to advanced microscopy, particularly superresolution microscopy.
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References
- ↑ "Francisco Balzarotti's lab at the IMP" . Retrieved 2023-07-19.
- ↑ https://www.linkedin.com/in/francisco-balzarotti/
- ↑ "Francisco Balzarotti | Light-based microscopy | Research Institute of Molecular Pathology (IMP)".
- ↑ "Stefan Hell".
- ↑ "Researchers achieve ultimate resolution limit in fluorescence microscopy".
- ↑ Balzarotti, Francisco; Eilers, Yvan; Gwosch, Klaus C.; Gynnå, Arvid H.; Westphal, Volker; Stefani, Fernando D.; Elf, Johan; Hell, Stefan W. (2017). "Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes". Science. 355 (6325): 606–612. arXiv: 1611.03401 . Bibcode:2017Sci...355..606B. doi:10.1126/science.aak9913. hdl:11858/00-001M-0000-002C-2D9A-4. PMID 28008086. S2CID 5418707.
- ↑ "First multimessenger observation of a neutron-star merger is Physics World 2017 Breakthrough of the Year". 11 December 2017.
- ↑ "Researchers achieve ultimate resolution limit in fluorescence microscopy".
- ↑ Eilers, Yvan; Ta, Haisen; Gwosch, Klaus C.; Balzarotti, Francisco; Hell, Stefan W. (2018). "MINFLUX monitors rapid molecular jumps with superior spatiotemporal resolution". Proceedings of the National Academy of Sciences. 115 (24): 6117–6122. doi: 10.1073/pnas.1801672115 . PMC 6004438 . PMID 29844182.
- ↑ Pape, Jasmin K.; Stephan, Till; Balzarotti, Francisco; Büchner, Rebecca; Lange, Felix; Riedel, Dietmar; Jakobs, Stefan; Hell, Stefan W. (2020). "Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins". Proceedings of the National Academy of Sciences. 117 (34): 20607–20614. Bibcode:2020PNAS..11720607P. doi: 10.1073/pnas.2009364117 . PMC 7456099 . PMID 32788360.
- ↑ Gwosch, Klaus C.; Pape, Jasmin K.; Balzarotti, Francisco; Hoess, Philipp; Ellenberg, Jan; Ries, Jonas; Hell, Stefan W. (2020). "MINFLUX nanoscopy delivers 3D multicolor nanometer resolution in cells". Nature Methods. 17 (2): 217–224. doi:10.1038/s41592-019-0688-0. PMID 31932776. S2CID 256840140.
- ↑ "Francisco Balzarotti | Light-based microscopy | Research Institute of Molecular Pathology (IMP)".
- ↑ https://www.balzarotti-lab.org/
- ↑ "Francisco Balzarotti | Research at a molecular biology institute when you are not a biologist". YouTube .
- ↑ "Seeing is Believing: Imaging the Molecular Processes of Life – Course and Conference Office".
- ↑ "Program".
- ↑ https://smlms.org/
- ↑ "ERC Starting Grants 2019 – List of Principal Investigators" (PDF). Retrieved 2023-07-19.
- ↑ "High-throughput 4D imaging for nanoscale cellular studies" . Retrieved 2023-07-19.
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