MPIG6B | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | MPIG6B , G6b, NG31, C6orf25, G6B, chromosome 6 open reading frame 25, G6b-B, megakaryocyte and platelet inhibitory receptor G6b, THAMY | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 606520 MGI: 2146995 HomoloGene: 82249 GeneCards: MPIG6B | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Protein G6b is a protein that in humans is encoded by the G6B gene, or C6orf25. [5] [6] [7]
This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [7]
Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.
Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.
Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene. NCR1 has also been designated as CD335 (cluster of differentiation, NKP46, NKp46, NK-p46, and LY94.
Killer cell immunoglobulin-like receptor 3DL2 is a protein that in humans is encoded by the KIR3DL2 gene.
Minor histocompatibility antigen H13 is a protein that in humans is encoded by the HM13 gene.
Leukocyte-specific transcript 1 protein is a protein that in humans is encoded by the LST1 gene.
SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.
Butyrophilin subfamily 1 member A1 is a protein that in humans is encoded by the BTN1A1 gene.
Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.
Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene. IGSF8 has also been designated as CD316.
Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene. SIRPB1 has also recently been designated CD172B.
C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.
Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene.
Leukocyte immunoglobulin-like receptor subfamily A member 2 is a protein that in humans is encoded by the LILRA2 gene.
Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.
CD8a, is a human gene.
CD1a is a human protein encoded by the CD1A gene.
Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.
Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.
CD96 or Tactile is a protein that in humans is encoded by the CD96 gene. CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226. The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.