GALNT11

GALNT11
Identifiers
Aliases	GALNT11 , GALNACT11, GALNAC-T11, polypeptide N-acetylgalactosaminyltransferase 11
External IDs	OMIM: 615130 MGI: 2444392 HomoloGene: 11126 GeneCards: GALNT11
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q36.1|7q36.1 Start 152,025,674 bp [1] End 152,122,347 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 A3- B1 Start 25,426,902 bp [2] End 25,470,916 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla kidney tubule retinal pigment epithelium Brodmann area 23 glomerulus middle temporal gyrus metanephric glomerulus tibia visceral pleura parietal pleura Top expressed in proximal tubule kidney visual cortex yolk sac condyle sciatic nerve islet of Langerhans superior frontal gyrus neural tube medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glycosyltransferase activity metal ion binding Notch binding carbohydrate binding polypeptide N-acetylgalactosaminyltransferase activity Cellular component integral component of membrane Golgi apparatus membrane Golgi membrane Biological process Notch signaling pathway cilium assembly protein glycosylation protein O-linked glycosylation via threonine determination of left/right symmetry O-glycan processing Notch receptor processing regulation of Notch signaling pathway Notch signaling involved in heart development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63917 231050 Ensembl ENSG00000178234 ENSMUSG00000038072 UniProt Q8NCW6 Q921L8 RefSeq (mRNA) NM_001304514 NM_022087 NM_144908 NM_001359890 RefSeq (protein) NP_001291443 NP_071370 NP_001358387 NP_001358388 NP_001358389 NP_001358390 NP_001358391 NP_001358392 NP_001358393 NP_001358394 NP_001358395 NP_001358396 NP_001358397 NP_001358398 NP_001358399 NP_001358400 NP_001358401 NP_001358402 NP_001358403 NP_001358404 NP_659157 NP_001346819 Location (UCSC) Chr 7: 152.03 – 152.12 Mb Chr 5: 25.43 – 25.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Polypeptide N-acetylgalactosaminyltransferase 11 is an enzyme that in humans is encoded by the GALNT11 gene. ^{[5] [6]}

The GALNT11 gene contains 10 exons. ^[7] An important paralog of this gene is GALNTL5. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000178234 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038072 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schwientek T, Bennett EP, Flores C, Thacker J, Hollmann M, Reis CA, Behrens J, Mandel U, Keck B, Schafer MA, Haselmann K, Zubarev R, Roepstorff P, Burchell JM, Taylor-Papadimitriou J, Hollingsworth MA, Clausen H (Jun 2002). "Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila". J Biol Chem. 277 (25): 22623–38. doi: 10.1074/jbc.M202684200 . PMID   11925450.
6. "Entrez Gene: GALNT11 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)".
7. "UDP-N-ACETYL-ALPHA-D-GALACTOSAMINE:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 11; GALNT11".
8. "GALNT11 Gene (Protein Coding)".

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.