GARNL1

RALGAPA1
Identifiers
Aliases	RALGAPA1 , GARNL1, GRIPE, RalGAPalpha1, TULIP1, p240, Ral GTPase activating protein catalytic alpha subunit 1, Ral GTPase activating protein catalytic subunit alpha 1, NEDHRIT
External IDs	OMIM: 608884; MGI: 1931050; HomoloGene: 84805; GeneCards: RALGAPA1; OMA:RALGAPA1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q13.2 Start 35,538,352 bp [1] End 35,809,304 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C1 Start 55,602,896 bp [2] End 55,821,167 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Achilles tendon corpus callosum lateral nuclear group of thalamus sural nerve inferior olivary nucleus dorsal motor nucleus of vagus nerve pars compacta Epithelium of choroid plexus external globus pallidus Top expressed in ascending aorta visual cortex primary visual cortex aortic valve superior frontal gyrus cerebellar cortex primary motor cortex granulocyte medial dorsal nucleus mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity protein heterodimerization activity Cellular component cytoplasm nucleus Biological process regulation of small GTPase mediated signal transduction activation of GTPase activity positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 253959 56784 Ensembl ENSG00000174373 ENSMUSG00000021027 UniProt Q6GYQ0 Q6GYP7 RefSeq (mRNA) NM_001283043 NM_001283044 NM_014990 NM_194301 NM_001330075 NM_001346243 NM_001346245 NM_001346246 NM_001346247 NM_001346248 NM_001346249 NM_001003719 NM_001112714 NM_001286263 NM_019994 NM_001368814 RefSeq (protein) NP_001269972 NP_001269973 NP_001317004 NP_001333172 NP_001333174 NP_001333175 NP_001333176 NP_001333177 NP_001333178 NP_055805 NP_919277 NP_001003719 NP_001106185 NP_001273192 NP_064378 NP_001355743 Location (UCSC) Chr 14: 35.54 – 35.81 Mb Chr 12: 55.6 – 55.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GTPase-activating Rap/Ran-GAP domain-like 1 is an enzyme that in humans is encoded by the RALGAPA1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000174373 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021027 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shirakawa R, Fukai S, Kawato M, Higashi T, Kondo H, Ikeda T, Nakayama E, Okawa K, Nureki O, Kimura T, Kita T, Horiuchi H (Aug 2009). "Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases". J Biol Chem. 284 (32): 21580–8. doi: 10.1074/jbc.M109.012112 . PMC   2755882 . PMID   19520869.
6. "Entrez Gene: GARNL1 GTPase activating Rap/RanGAP domain-like 1".

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
• Heng JI, Tan SS (2003). "Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain". J. Biol. Chem. 277 (45): 43152–9. doi: 10.1074/jbc.M204858200 . PMID   12200424.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Swaminathan S, Kiendl F, Körner R, et al. (2004). "RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly". J. Cell Biol. 164 (7): 965–71. doi:10.1083/jcb.200309126. PMC   2172064 . PMID   15037602.
• Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLOS Biol. 2 (7): E207. doi: 10.1371/journal.pbio.0020207 . PMC   449870 . PMID   15252450.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Schwarzbraun T, Vincent JB, Schumacher A, et al. (2005). "Cloning, genomic structure, and expression profiles of TULIP1 (GARNL1), a brain-expressed candidate gene for 14q13-linked neurological phenotypes, and its murine homologue". Genomics. 84 (3): 577–86. doi:10.1016/j.ygeno.2004.04.013. PMID   15498464.
• Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly". PLOS Biol. 4 (9): e262. doi: 10.1371/journal.pbio.0040262 . PMC   1540706 . PMID   16903783.