GBF1

GBF1
Identifiers
Aliases	GBF1 , ARF1GEF, golgi brefeldin A resistant guanine nucleotide exchange factor 1, CMT2GG
External IDs	OMIM: 603698 MGI: 1861607 HomoloGene: 37897 GeneCards: GBF1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	102,382,899 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	46,274,949 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; sural nerve; ; stromal cell of endometrium; ; ganglionic eminence; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right uterine tube; ; right lobe of liver; ; minor salivary gland; ; skin of abdomen;
	Top expressed in
	lacrimal gland; ; secondary oocyte; ; seminiferous tubule; ; molar; ; parotid gland; ; spermatocyte; ; spermatid; ; superior frontal gyrus; ; internal carotid artery; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3,5-bisphosphate binding ; protein binding ; guanyl-nucleotide exchange factor activity ; phosphatidylinositol-3,4,5-trisphosphate binding ; lipid binding ;
Cellular component	lipid droplet ; Golgi membrane ; trans-Golgi network ; cell leading edge ; peroxisome ; cytoplasm ; endoplasmic reticulum lumen ; Golgi stack ; mitochondrion ; cytosol ; Golgi apparatus ; membrane ; cis-Golgi network ; endoplasmic reticulum-Golgi intermediate compartment ;
Biological process	Golgi disassembly ; protein localization to endoplasmic reticulum tubular network ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ; protein transport ; Golgi organization ; viral process ; regulation of mitotic cell cycle ; endoplasmic reticulum-Golgi intermediate compartment organization ; post-Golgi vesicle-mediated transport ; establishment of monopolar cell polarity ; protein localization to endoplasmic reticulum exit site ; regulation of protein localization to cell surface ; endoplasmic reticulum to Golgi vesicle-mediated transport ; cell activation involved in immune response ; protein localization to Golgi apparatus ; neutrophil chemotaxis ; reactive oxygen species biosynthetic process ; retrograde transport, endosome to Golgi ; Golgi to endosome transport ; regulation of ARF protein signal transduction ; COPI coating of Golgi vesicle ; transport ; regulation of molecular function ;
	Sources:Amigo / QuickGO
Orthologs
	8729
	107338
	ENSG00000107862
	ENSMUSG00000025224
	Q92538
	n/a
NM_001199378 ; NM_001199379 ; NM_004193 ; NM_001377137 ; NM_001377138 ;
	NM_001377139 ; NM_001377140 ; NM_001377141 ; NM_001391922 ; NM_001391923 ; NM_001391924 ; NM_001391925 ; NM_001391926 ; NM_001391927 ; NM_001391928 ; NM_001391929 ; NM_001391930 ; NM_001391931
	NM_178930
	NP_001186307 ; NP_001186308 ; NP_004184
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 13, 2023

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.^[5]^[6]

Related Research Articles

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

Brefeldin A is a lactone antiviral produced by the fungus Penicillium brefeldianum. Brefeldin A inhibits protein transport from the endoplasmic reticulum to the golgi complex indirectly by preventing association of COP-I coat to the Golgi membrane. Brefeldin A was initially isolated with hopes to become an antiviral drug but is now primarily used in research to study protein transport.

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

Cytohesin-1 formerly known as Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a protein that in humans is encoded by the CYTH1 gene.

ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene.

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene.

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ASAP2 gene.

Mitochondrial GTPase 1 is an enzyme that in humans is encoded by the MTG1 gene.

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP₁₀₀ (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene.

Dedicator of cytokinesis protein 9 (Dock9) also known as Zizimin1, is a large protein encoded in the human by the DOCK9 gene, involved in intracellular signalling networks. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors that function as activators of small G-proteins. Dock9 activates the small G protein Cdc42.

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.

IQ motif and Sec7 domain 2 is a protein that in humans is encoded by the IQSEC2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107862 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025224 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mansour SJ, Herbrick JA, Scherer SW, Melancon P (Jan 1999). "Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24". Genomics. 54 (2): 323–7. doi:10.1006/geno.1998.5563. PMID 9828135.
↑ "Entrez Gene: GBF1 golgi-specific brefeldin A resistance factor 1".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID 9039502.
Claude A, Zhao BP, Kuziemsky CE, et al. (1999). "GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5". J. Cell Biol. 146 (1): 71–84. doi:10.1083/jcb.146.1.71. PMC 2199737 . PMID 10402461.
Kawamoto K, Yoshida Y, Tamaki H, et al. (2003). "GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat". Traffic. 3 (7): 483–95. doi: 10.1034/j.1600-0854.2002.30705.x . PMID 12047556. S2CID 45336536.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
García-Mata R, Sztul E (2003). "The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor". EMBO Rep. 4 (3): 320–5. doi:10.1038/sj.embor.embor762. PMC 1315890 . PMID 12634853.
Claude A, Zhao BP, Melançon P (2003). "Characterization of alternatively spliced and truncated forms of the Arf guanine nucleotide exchange factor GBF1 defines regions important for activity". Biochem. Biophys. Res. Commun. 303 (1): 160–9. doi:10.1016/S0006-291X(03)00316-4. hdl: 10533/173991 . PMID 12646181.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi: 10.1016/j.cub.2004.07.051 . PMID 15324660. S2CID 2371325.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Niu TK, Pfeifer AC, Lippincott-Schwartz J, Jackson CL (2005). "Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi". Mol. Biol. Cell. 16 (3): 1213–22. doi:10.1091/mbc.E04-07-0599. PMC 551486 . PMID 15616190.
Szul T, Garcia-Mata R, Brandon E, et al. (2005). "Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1". Traffic. 6 (5): 374–85. doi: 10.1111/j.1600-0854.2005.00282.x . PMID 15813748. S2CID 23845874.
Roy SK, Hu J, Meng Q, et al. (2006). "Development of monoclonal antibodies against GBF1 and their use in studying its functions". J. Interferon Cytokine Res. 25 (11): 666–73. doi:10.1089/jir.2005.25.666. PMID 16318580.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
Zhao X, Claude A, Chun J, et al. (2006). "GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic". J. Cell Sci. 119 (Pt 18): 3743–53. doi: 10.1242/jcs.03173 . PMID 16926190.
Belov GA, Altan-Bonnet N, Kovtunovych G, et al. (2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA". J. Virol. 81 (2): 558–67. doi:10.1128/JVI.01820-06. PMC 1797456 . PMID 17079330.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107862 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025224 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9828135-5] Mansour SJ, Herbrick JA, Scherer SW, Melancon P (Jan 1999). "Human GBF1 is a ubiquitously expressed gene of the sec7 domain family mapping to 10q24". Genomics. 54 (2): 323–7. doi:10.1006/geno.1998.5563. PMID 9828135.

[entrez-6] "Entrez Gene: GBF1 golgi-specific brefeldin A resistance factor 1".

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GBF1

Related Research Articles

References

Further reading