GFM2

GFM2
Identifiers
Aliases	GFM2 , EF-G2mt, EFG2, MRRF2, MST027, RRF2, RRF2mt, hEFG2, mEF-G 2, MSTP027, G elongation factor, mitochondrial 2, G elongation factor mitochondrial 2, RRF, GTP dependent ribosome recycling factor mitochondrial 2
External IDs	OMIM: 606544 MGI: 2444783 HomoloGene: 6238 GeneCards: GFM2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	74,767,147 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	97,181,195 bp
Gene ontology
Molecular function	• translation elongation factor activity ; • nucleotide binding ; • GTP binding ; • GO:0001948 protein binding ; • GO:0006184 GTPase activity ;
Cellular component	• mitochondrial matrix ; • mitochondrion ;
Biological process	• mitochondrial translational termination ; • mitochondrial translational elongation ; • ribosome disassembly ; • protein biosynthesis ; • mitochondrial translation ; • translational elongation ;
	Sources:Amigo / QuickGO
Orthologs
	84340
	320806
	ENSG00000164347
	ENSMUSG00000021666
	Q969S9
	Q8R2Q4
	NM_001281302 ; NM_032380 ; NM_170681 ; NM_170691
	NM_001146043 ; NM_001271463 ; NM_001271464 ; NM_001271465 ; NM_177266
	NP_001268231 ; NP_115756 ; NP_733781 ; NP_733792 ; NP_733792.1
	NP_001139515 ; NP_001258392 ; NP_001258393 ; NP_001258394 ; NP_796240
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 06, 2021

Ribosome-releasing factor 2, mitochondrial is a protein that in humans is encoded by the GFM2 gene. ^[5]^[6] Unlike the other EF-G homolog GFM1, GFM2 functions as a Ribosome Recycling Factor in termination.^[7]

Related Research Articles

Ribosome recycling factor or ribosome release factor (RRF) is a protein found in bacterial cells as well as eukaryotic organelles, specifically mitochondria and chloroplasts. It functions to recycle ribosomes after completion of protein synthesis. In humans, the mitochrondrial version is coded by the MRRF gene.

Elongation factor 1-delta is a protein that in humans is encoded by the EEF1D gene.

Elongation factor 1-beta is a protein that in humans is encoded by the EEF1B2 gene.

Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic counterpart of bacterial EF-G.

Elongation factor 1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene.

Elongation factor Tu, mitochondrial is a protein that in humans is encoded by the TUFM gene. It is an EF-Tu homolog.

28S ribosomal protein S22, mitochondrial is a protein that in humans is encoded by the MRPS22 gene.

Elongation factor G 1, mitochondrial is a protein that in humans is encoded by the GFM1 gene. It is an EF-G homolog.

39S ribosomal protein L19, mitochondrial is a protein that in humans is encoded by the MRPL19 gene.

39S ribosomal protein L30, mitochondrial is a protein that in humans is encoded by the MRPL30 gene.

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene.

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.

28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene.

EF-G is a prokaryotic elongation factor involved in protein translation. As a GTPase, EF-G catalyzes the movement (translocation) of transfer RNA (tRNA) and messenger RNA (mRNA) through the ribosome.

Elongation factor Ts, mitochondrial is a protein that in humans is encoded by the TSFM gene. It is an EF-Ts homolog.

39S ribosomal protein L23, mitochondrial is a protein that in humans is encoded by the MRPL23 gene.

39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.

39S ribosomal protein L10, mitochondrial is a protein that in humans is encoded by the MRPL10 gene.

Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.

Mitochondrial inner membrane protein OXA1L is a protein that in humans is encoded by the OXA1L gene located on 14q11.2. The C-terminus of this protein interacts with mitochondrial ribosomes and helps insert both mitochondrial and nuclear produced proteins into the inner membrane of the mitochondria.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164347 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021666 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grandér D, Sangfelt O (November 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Human Genetics. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.
↑ "Entrez Gene: GFM2 G elongation factor, mitochondrial 2".
↑ Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N (August 2009). "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis". Molecular Cell. 35 (4): 502–10. doi: 10.1016/j.molcel.2009.06.028 . PMID 19716793.

External links

InterPro : IPR030851

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164347 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021666 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11735030-5] Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grandér D, Sangfelt O (November 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Human Genetics. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.

[entrez-6] "Entrez Gene: GFM2 G elongation factor, mitochondrial 2".

[7] Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N (August 2009). "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis". Molecular Cell. 35 (4): 502–10. doi: 10.1016/j.molcel.2009.06.028 . PMID 19716793.

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