GINS1

GINS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9X, 2EHO, 2Q9Q
Identifiers
Aliases	GINS1 , PSF1, GINS complex subunit 1, IMD55
External IDs	OMIM: 610608; MGI: 1916520; HomoloGene: 44516; GeneCards: GINS1; OMA:GINS1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p11.21 Start 25,391,008 bp [1] End 25,452,700 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 G3 Start 150,747,320 bp [2] End 150,773,200 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte sperm embryo ventricular zone right testis left testis ganglionic eminence endothelial cell trabecular bone Top expressed in medial ganglionic eminence primitive streak fetal liver hematopoietic progenitor cell otic vesicle ventricular zone spermatocyte tail of embryo otic placode abdominal wall primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3'-5' DNA helicase activity Cellular component cytoplasm nucleus nucleoplasm GINS complex Biological process DNA replication DNA strand elongation involved in mitotic DNA replication DNA strand elongation involved in DNA replication inner cell mass cell proliferation DNA duplex unwinding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9837 69270 Ensembl ENSG00000101003 ENSMUSG00000027454 UniProt Q14691 Q9CZ15 RefSeq (mRNA) NM_021067 NM_001163476 NM_027014 RefSeq (protein) NP_066545 NP_001156948 NP_081290 Location (UCSC) Chr 20: 25.39 – 25.45 Mb Chr 2: 150.75 – 150.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA replication complex GINS protein PSF1 is a protein that in humans is encoded by the GINS1 gene. ^{[5] [6] [7]}

See also

• GINS (protein complex)
• Eukaryotic DNA replication#GINS Explains role of GINS during DNA replication in eukaryotic cells.

References

1. GRCh38: Ensembl release 89: ENSG00000101003 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027454 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi: 10.1093/dnares/3.1.17 . PMID   8724849.
6. Chiang PW, Wang S, Smithivas P, Song WJ, Ramamoorthy S, Hillman J, Puett S, Van Keuren ML, Crombez E, Kumar A, Glover TW, Miller DE, Tsai CH, Blackburn CC, Chen XN, Sun Z, Cheng JF, Korenberg JR, Kurnit DM (Sep 1996). "Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h". Genomics. 34 (3): 328–33. doi:10.1006/geno.1996.0294. PMID   8786132.
7. "Entrez Gene: GINS1 GINS complex subunit 1 (Psf1 homolog)".

Further reading

• Kamada K, Kubota Y, Arata T, et al. (2007). "Structure of the human GINS complex and its assembly and functional interface in replication initiation". Nat. Struct. Mol. Biol. 14 (5): 388–96. doi:10.1038/nsmb1231. PMID   17417653. S2CID   23124923.
• Hayashi R, Arauchi T, Tategu M, et al. (2007). "A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS". Genomics Proteomics Bioinformatics. 4 (3): 156–64. doi:10.1016/S1672-0229(06)60028-4. PMC   5054078 . PMID   17127213.
• Ueno M, Itoh M, Kong L, et al. (2005). "PSF1 is essential for early embryogenesis in mice". Mol. Cell. Biol. 25 (23): 10528–32. doi:10.1128/MCB.25.23.10528-10532.2005. PMC   1291228 . PMID   16287864.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID   10942595.