GLCE

GLCE
Identifiers
Aliases	GLCE , HSEPI, glucuronic acid epimerase
External IDs	OMIM: 612134 MGI: 2136405 HomoloGene: 14111 GeneCards: GLCE
Gene location (Human)
Chr.	Chromosome 15 (human)
End	69,272,217 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	62,029,937 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; Achilles tendon; ; ganglionic eminence; ; rectum; ; endothelial cell; ; islet of Langerhans; ; secondary oocyte; ; monocyte; ; minor salivary gland; ; right lobe of liver;
	Top expressed in
	saccule; ; otic placode; ; secondary oocyte; ; cumulus cell; ; medullary collecting duct; ; nucleus accumbens; ; habenula; ; seminal vesicula; ; olfactory tubercle; ; stria vascularis;
	More reference expression data
	n/a
Gene ontology
Molecular function	racemase and epimerase activity, acting on carbohydrates and derivatives ; isomerase activity ; heparosan-N-sulfate-glucuronate 5-epimerase activity ;
Cellular component	integral component of membrane ; Golgi membrane ; Golgi apparatus ; membrane ;
Biological process	heparan sulfate proteoglycan biosynthetic process ; heparin biosynthetic process ; glycosaminoglycan biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	26035
	93683
	ENSG00000138604
	ENSMUSG00000032252
	O94923
	Q9EPS3
	NM_015554 ; NM_001324091 ; NM_001324092 ; NM_001324093 ; NM_001324094
	NM_033320 ; NM_001368304
	NP_001311020 ; NP_001311021 ; NP_001311022 ; NP_001311023 ; NP_056369
	NP_201577 ; NP_001355233
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 26, 2022

D-glucuronyl C5-epimerase is an enzyme that in humans is encoded by the GLCE gene.^[5]^[6]

Related Research Articles

Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. It is in this form that HS binds to a variety of protein ligands, including Wnt, and regulates a wide range of biological activities, including developmental processes, angiogenesis, blood coagulation, abolishing detachment activity by GrB, and tumour metastasis. HS has also been shown to serve as cellular receptor for a number of viruses, including the respiratory syncytial virus. One study suggests that cellular heparan sulfate has a role in SARS-CoV-2 Infection, particularly when the virus attaches with ACE2.

In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 1 is an enzyme that catalyzes the chemical reaction

Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene.

Syndecan-3 is a protein that in humans is encoded by the SDC3 gene.

N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Exostosin-like 3 is a protein that in humans is encoded by the EXTL3 gene.

Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.

Dermatan-sulfate epimerase is an enzyme that in humans is encoded by the DSE gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.

Exostosin-like 2 is a protein that in humans is encoded by the EXTL2 gene. EXTL2 Glycosyltransferase is required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138604 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032252 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ghiselli G, Agrawal A (Aug 2005). "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the β-catenin–TCF4 pathway". Biochem J. 390 (Pt 2): 493–9. doi:10.1042/BJ20050152. PMC 1198929 . PMID 15853773.
↑ "Entrez Gene: GLCE glucuronic acid epimerase".

Grigorieva E, Eshchenko T, Rykova VI, et al. (2008). "Decreased expression of human D-glucuronyl C5-epimerase in breast cancer". Int. J. Cancer. 122 (5): 1172–6. doi: 10.1002/ijc.23203 . PMID 17985344.
Hagner-McWhirter A, Li JP, Oscarson S, Lindahl U (2004). "Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate". J. Biol. Chem. 279 (15): 14631–8. doi: 10.1074/jbc.M313760200 . PMID 14718527.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Crawford BE, Olson SK, Esko JD, Pinhal MA (2001). "Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase". J. Biol. Chem. 276 (24): 21538–43. doi: 10.1074/jbc.M100880200 . PMID 11279150.
Li JP, Gong F, El Darwish K, et al. (2001). "Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate". J. Biol. Chem. 276 (23): 20069–77. doi: 10.1074/jbc.M011783200 . PMID 11274177.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID 10048485.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID 8889549.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138604 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032252 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15853773-5] Ghiselli G, Agrawal A (Aug 2005). "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the β-catenin–TCF4 pathway". Biochem J. 390 (Pt 2): 493–9. doi:10.1042/BJ20050152. PMC 1198929 . PMID 15853773.

[entrez-6] "Entrez Gene: GLCE glucuronic acid epimerase".

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GLCE

Related Research Articles

References

Further reading