GLTP

GLTP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SWX, 1SX6, 2EUK, 2EUM, 2EVD, 2EVL, 2EVS, 2EVT, 3RIC, 3RWV, 3RZN, 3S0I, 3S0K, 4GH0, 4GHP, 4GHS, 4GIX, 4GJQ, 4GVT, 4GXD, 4GXG, 4H2Z
Identifiers
Aliases	GLTP , glycolipid transfer protein
External IDs	OMIM: 608949 MGI: 1929253 HomoloGene: 41133 GeneCards: GLTP
Gene location (Human)
Chr.	Chromosome 12 (human)
End	109,880,541 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	114,829,045 bp
RNA expression pattern
	Top expressed in
	human penis; ; vulva; ; cavity of mouth; ; nipple; ; pancreatic ductal cell; ; inferior ganglion of vagus nerve; ; body of tongue; ; skin of abdomen; ; spinal cord; ; endothelial cell;
	Top expressed in
	superior surface of tongue; ; epidermis; ; lip; ; hair follicle; ; skin of back; ; esophagus; ; skin of abdomen; ; condyle; ; belly cord; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; lipid binding ; glycolipid transfer activity ; glycolipid binding ; lipid transfer activity ; identical protein binding ; ceramide 1-phosphate binding ; ceramide 1-phosphate transfer activity ;
Cellular component	cytoplasm ; cytosol ; membrane ;
Biological process	lipid transport ; glycosphingolipid metabolic process ; glycolipid transport ; intermembrane lipid transfer ; ceramide transport ; ceramide 1-phosphate transport ;
	Sources:Amigo / QuickGO
Orthologs
	51228
	56356
	ENSG00000139433
	ENSMUSG00000011884
	Q9NZD2
	Q9JL62
	NM_016433
	NM_019821
	NP_057517
	NP_062795
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Glycolipid transfer protein is a protein that in humans is encoded by the GLTP gene.^[5]^[6]^[7]

The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein.^[7]

Related Research Articles

Glycolipid transfer protein is a cytosolic protein that catalyses the transfer of glycolipids between different intracellular membranes.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000139433 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011884 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Li XM, Malakhova ML, Lin X, Pike HM, Chung T, Molotkovsky JG, Brown RE (Aug 2004). "Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy". Biochemistry. 43 (31): 10285–94. doi:10.1021/bi0495432. PMC 2593833 . PMID 15287756.
↑ Malakhova ML, Malinina L, Pike HM, Kanack AT, Patel DJ, Brown RE (Jul 2005). "Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex". J Biol Chem. 280 (28): 26312–20. doi: 10.1074/jbc.M500481200 . PMC 1393170 . PMID 15901739.
1 2 "Entrez Gene: GLTP glycolipid transfer protein".

Brown RE, Mattjus P (2007). "Glycolipid transfer proteins". Biochim. Biophys. Acta. 1771 (6): 746–60. doi:10.1016/j.bbalip.2007.01.011. PMC 1986823 . PMID 17320476.
Abe A (1990). "Primary structure of glycolipid transfer protein from pig brain". J. Biol. Chem. 265 (17): 9634–7. doi: 10.1016/S0021-9258(19)38716-2 . PMID 2190982.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Mattjus P, Pike HM, Molotkovsky JG, Brown RE (2000). "Charged membrane surfaces impede the protein-mediated transfer of glycosphingolipids between phospholipid bilayers". Biochemistry. 39 (5): 1067–75. doi:10.1021/bi991810u. PMC 2637181 . PMID 10653652.
Lin X, Mattjus P, Pike HM, et al. (2000). "Cloning and expression of glycolipid transfer protein from bovine and porcine brain". J. Biol. Chem. 275 (7): 5104–10. doi: 10.1074/jbc.275.7.5104 . PMC 2621014 . PMID 10671554.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Malinina L, Malakhova ML, Teplov A, et al. (2004). "Structural basis for glycosphingolipid transfer specificity". Nature. 430 (7003): 1048–53. Bibcode:2004Natur.430.1048M. doi:10.1038/nature02856. PMC 2640488 . PMID 15329726.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rao CS, Lin X, Pike HM, et al. (2004). "Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses". Biochemistry. 43 (43): 13805–15. doi:10.1021/bi0492197. PMC 2596630 . PMID 15504043.
Rao CS, Chung T, Pike HM, Brown RE (2006). "Glycolipid transfer protein interaction with bilayer vesicles: modulation by changing lipid composition". Biophys. J. 89 (6): 4017–28. doi:10.1529/biophysj.105.070631. PMC 1366967 . PMID 16169991.
Malinina L, Malakhova ML, Kanack AT, et al. (2006). "The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure". PLOS Biol. 4 (11): e362. doi: 10.1371/journal.pbio.0040362 . PMC 1618416 . PMID 17105344.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000139433 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011884 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15287756-5] Li XM, Malakhova ML, Lin X, Pike HM, Chung T, Molotkovsky JG, Brown RE (Aug 2004). "Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy". Biochemistry. 43 (31): 10285–94. doi:10.1021/bi0495432. PMC 2593833 . PMID 15287756.

[pmid15901739-6] Malakhova ML, Malinina L, Pike HM, Kanack AT, Patel DJ, Brown RE (Jul 2005). "Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex". J Biol Chem. 280 (28): 26312–20. doi: 10.1074/jbc.M500481200 . PMC 1393170 . PMID 15901739.

[entrez-7] 1 2 "Entrez Gene: GLTP glycolipid transfer protein".

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GLTP

Related Research Articles

References

Further reading