GMDS (gene)

GMDS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T2A
Identifiers
Aliases	GMDS , GMD, SDR3E1, GDP-mannose 4,6-dehydratase
External IDs	OMIM: 602884; MGI: 1891112; HomoloGene: 75968; GeneCards: GMDS; OMA:GMDS - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p25.3 Start 1,623,806 bp [1] End 2,245,605 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A3.2 Start 32,003,562 bp [2] End 32,522,723 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland mucosa of transverse colon Descending thoracic aorta rectum ascending aorta duodenum minor salivary glands palpebral conjunctiva right coronary artery mucosa of sigmoid colon Top expressed in Paneth cell epithelium of stomach large intestine colon duodenum jejunum left colon ileum rib epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding NADP+ binding lyase activity GDP-mannose 4,6-dehydratase activity identical protein binding Cellular component cytosol extracellular exosome cytoplasm Biological process GDP-mannose metabolic process 'de novo' GDP-L-fucose biosynthetic process Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2762 218138 Ensembl ENSG00000112699 ENSMUSG00000038372 UniProt O60547 Q8K0C9 RefSeq (mRNA) NM_001253846 NM_001500 NM_146041 RefSeq (protein) NP_001240775 NP_001491 NP_666153 Location (UCSC) Chr 6: 1.62 – 2.25 Mb Chr 13: 32 – 32.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GDP-mannose 4,6 dehydratase is an enzyme that in humans is encoded by the GMDS gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000112699 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038372 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, et al. (May 1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro". J Biol Chem. 273 (14): 8193–8202. doi: 10.1074/jbc.273.14.8193 . PMID   9525924.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, et al. (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
7. "Entrez Gene: GMDS GDP-mannose 4,6-dehydratase".

Further reading

• Ohyama C, Smith PL, Angata K, Fukuda MN, Lowe JB, Fukuda M (1998). "Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells". J. Biol. Chem. 273 (23): 14582–14587. doi: 10.1074/jbc.273.23.14582 . PMID   9603974.
• Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–3175. doi: 10.1074/jbc.M107927200 . PMID   11698403.
• Eshel R, Besser M, Zanin A, Sagi-Assif O, Witz IP (2002). "The FX enzyme is a functional component of lymphocyte activation". Cell. Immunol. 213 (2): 141–148. doi:10.1006/cimm.2001.1872. PMID   11831876.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.