GMEB2

GMEB2
Identifiers
Aliases	GMEB2 , P79PIF, PIF79, GMEB-2, glucocorticoid modulatory element binding protein 2
External IDs	OMIM: 607451 MGI: 2652836 HomoloGene: 8228 GeneCards: GMEB2
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.33 Start 63,587,602 bp [1] End 63,627,101 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H4 Start 180,893,242 bp [2] End 180,929,828 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland thymus mucosa of urinary bladder pancreatic ductal cell right lobe of thyroid gland tibialis anterior muscle blood left lobe of thyroid gland oocyte endothelial cell Top expressed in hand otolith organ utricle cumulus cell blood medial ganglionic eminence thymus bone marrow foot spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding transcription coactivator activity metal ion binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytoplasm cytosol Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26205 229004 Ensembl ENSG00000101216 ENSMUSG00000038705 UniProt Q9UKD1 P58929 RefSeq (mRNA) NM_012384 NM_198169 RefSeq (protein) NP_036516 NP_937812 Location (UCSC) Chr 20: 63.59 – 63.63 Mb Chr 2: 180.89 – 180.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glucocorticoid modulatory element-binding protein 2 is a protein that in humans is encoded by the GMEB2 gene. ^{[5] [6] [7]}

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000101216 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038705 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Christensen J, Cotmore SF, Tattersall P (Nov 1999). "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol. 19 (11): 7741–50. doi:10.1128/MCB.19.11.7741. PMC   84824 . PMID   10523663.
6. Burnett E, Christensen J, Tattersall P (Dec 2001). "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J Mol Biol. 314 (5): 1029–39. doi:10.1006/jmbi.2000.5198. PMID   11743720.
7. "Entrez Gene: GMEB2 glucocorticoid modulatory element binding protein 2".

Further reading

• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
• Kaul S, Blackford JA, Chen J, et al. (2000). "Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins". Mol. Endocrinol. 14 (7): 1010–27. doi: 10.1210/me.14.7.1010 . PMID   10894151.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Kaul S, Blackford JA, Cho S, Simons SS (2002). "Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors". J. Biol. Chem. 277 (15): 12541–9. doi: 10.1074/jbc.M112330200 . PMID   11812797.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.