GOLGA3

GOLGA3
Identifiers
Aliases	GOLGA3 , GCP170, MEA-2, golgin A3, Golgin 160
External IDs	OMIM: 602581 MGI: 96958 HomoloGene: 4308 GeneCards: GOLGA3
Gene location (Human)
Chr.	Chromosome 12 (human)
End	132,829,078 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	110,374,336 bp
RNA expression pattern
	Top expressed in
	tibia; ; thymus; ; internal globus pallidus; ; cardia; ; stromal cell of endometrium; ; saphenous vein; ; oocyte; ; pylorus; ; sural nerve; ; trachea;
	Top expressed in
	ankle; ; right ventricle; ; seminiferous tubule; ; molar; ; calvaria; ; medullary collecting duct; ; atrioventricular valve; ; myocardium of ventricle; ; soleus muscle; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; transporter activity ; cadherin binding ;
Cellular component	cytoplasm ; Golgi transport complex ; Golgi cisterna membrane ; cytosol ; Golgi membrane ; Golgi apparatus ; nucleolus ; membrane ; nucleus ; nucleoplasm ; extrinsic component of Golgi membrane ;
Biological process	intra-Golgi vesicle-mediated transport ; spermatogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	2802
	269682
	ENSG00000090615
	ENSMUSG00000029502
	Q08378
	P55937
	NM_001172557 ; NM_005895
	NM_008146 ; NM_001347389
	NP_001166028 ; NP_005886
	NP_001334318 ; NP_032172
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 01, 2024

Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene.^[5]^[6]^[7]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis.

This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.^[7]

Related Research Articles

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Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene.

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Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.

BET1-like protein is a protein that in humans is encoded by the BET1L gene.

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.

Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene.

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Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.

AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene.

Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.

Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene.

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.

Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function.

Golgin A7 is a protein that in humans is encoded by the GOLGA7 gene. It is an acylated Golgi protein that interacts with GCP170 protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000090615 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029502 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fritzler MJ, Hamel JC, Ochs RL, Chan EK (Jul 1993). "Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex". J Exp Med. 178 (1): 49–62. doi:10.1084/jem.178.1.49. PMC 2191081 . PMID 8315394.
↑ Maag RS, Mancini M, Rosen A, Machamer CE (Jun 2005). "Caspase-resistant Golgin-160 Disrupts Apoptosis Induced by Secretory Pathway Stress and Ligation of Death Receptors". Mol Biol Cell. 16 (6): 3019–27. doi:10.1091/mbc.E04-11-0971. PMC 1142444 . PMID 15829563.
1 2 "Entrez Gene: GOLGA3 golgi autoantigen, golgin subfamily a, 3".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Misumi Y, Sohda M, Yano A, et al. (1997). "Molecular characterization of GCP170, a 170-kDa protein associated with the cytoplasmic face of the Golgi membrane". J. Biol. Chem. 272 (38): 23851–8. doi: 10.1074/jbc.272.38.23851 . PMID 9295333.
Barr FA (1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins". Curr. Biol. 9 (7): 381–4. Bibcode:1999CBio....9..381B. doi: 10.1016/S0960-9822(99)80167-5 . PMID 10209123. S2CID 14404566.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800.
Mancini M, Machamer CE, Roy S, et al. (2000). "Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis". J. Cell Biol. 149 (3): 603–12. doi:10.1083/jcb.149.3.603. PMC 2174848 . PMID 10791974.
Bray JD, Chennathukuzhi VM, Hecht NB (2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics. 79 (6): 799–808. doi:10.1006/geno.2002.6779. PMID 12036294.
Hicks SW, Machamer CE (2002). "The NH2-terminal domain of Golgin-160 contains both Golgi and nuclear targeting information". J. Biol. Chem. 277 (39): 35833–9. doi: 10.1074/jbc.M206280200 . PMID 12130652.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ohta E, Misumi Y, Sohda M, et al. (2004). "Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170". J. Biol. Chem. 278 (51): 51957–67. doi: 10.1074/jbc.M310014200 . PMID 14522980.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hicks SW, Machamer CE (2005). "Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST". J. Biol. Chem. 280 (32): 28944–51. doi: 10.1074/jbc.M504937200 . PMID 15951434.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Sbodio JI, Hicks SW, Simon D, Machamer CE (2006). "GCP60 preferentially interacts with a caspase-generated golgin-160 fragment". J. Biol. Chem. 281 (38): 27924–31. doi: 10.1074/jbc.M603276200 . PMID 16870622.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Hicks SW, Horn TA, McCaffery JM, et al. (2007). "Golgin-160 promotes cell surface expression of the beta-1 adrenergic receptor". Traffic. 7 (12): 1666–77. doi:10.1111/j.1600-0854.2006.00504.x. PMID 17118120. S2CID 6554179.
Sbodio JI, Machamer CE (2007). "Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160". J. Biol. Chem. 282 (41): 29874–81. doi: 10.1074/jbc.M705794200 . PMID 17711851.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000090615 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029502 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8315394-5] Fritzler MJ, Hamel JC, Ochs RL, Chan EK (Jul 1993). "Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex". J Exp Med. 178 (1): 49–62. doi:10.1084/jem.178.1.49. PMC 2191081 . PMID 8315394.

[pmid15829563-6] Maag RS, Mancini M, Rosen A, Machamer CE (Jun 2005). "Caspase-resistant Golgin-160 Disrupts Apoptosis Induced by Secretory Pathway Stress and Ligation of Death Receptors". Mol Biol Cell. 16 (6): 3019–27. doi:10.1091/mbc.E04-11-0971. PMC 1142444 . PMID 15829563.

[entrez-7] 1 2 "Entrez Gene: GOLGA3 golgi autoantigen, golgin subfamily a, 3".

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GOLGA3

Related Research Articles

References

Further reading