GOLT1B

GOLT1B
Identifiers
Aliases	GOLT1B , GCT2, GOT1, GOT1B, YMR292W, CGI-141, golgi transport 1B
External IDs	OMIM: 615078 MGI: 1914214 HomoloGene: 41102 GeneCards: GOLT1B
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p12.1 Start 21,501,781 bp [1] End 21,518,408 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G2 Start 142,332,947 bp [2] End 142,349,584 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tibia islet of Langerhans endothelial cell palpebral conjunctiva external globus pallidus synovial joint Achilles tendon stromal cell of endometrium subthalamic nucleus Top expressed in ascending aorta aortic valve otic placode saccule neural tube spermatocyte supraoptic nucleus yolk sac morula belly cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity Cellular component integral component of membrane Golgi membrane Golgi apparatus endoplasmic reticulum membrane Biological process protein transport positive regulation of I-kappaB kinase/NF-kappaB signaling vesicle-mediated transport signal transduction transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51026 66964 Ensembl ENSG00000111711 ENSMUSG00000030245 UniProt Q9Y3E0 Q9CR60 RefSeq (mRNA) NM_016072 NM_025872 RefSeq (protein) NP_057156 NP_080148 Location (UCSC) Chr 12: 21.5 – 21.52 Mb Chr 6: 142.33 – 142.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vesicle transport protein GOT1B is a protein that in humans is encoded by the GOLT1B gene. ^{[5] [6] [7]}

Got1p is a protein that aides in vesicle transport through the Golgi apparatus of the cell. ^[8] Got1p has a calculated mass of 15.4 kDa and consists of 138 residues. It is believed that the protein is a tetra-spanning membrane protein, and is evolutionarily conserved. Homologes of the protein have been found in Caenorhabditis elegans , Plasmodium falciparum , and in mammals. GOT1 is normally associated closely with Sf2p (encoded by sft2), which is another protein of similar function. In vivo, It has been found that the removal of these two proteins results in defects in endosome-Golgi traffic and ER-Golgi traffic. In vitro, the removal of got1 specifically, results in a defect in ER-Golgi transport in relation to vesicle tethering to Golgi membranes. The exact contribution that the protein has towards vesicle tethering is still a mystery, however, it is suspected that Got1p is involved in the release of Ca²⁺ in the Golgi membranes, causing ion channels associated with vesicle tethering to be affected. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000111711 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030245 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bourdon V, Naef F, Rao PH, Reuter V, Mok SC, Bosl GJ, Koul S, Murty VV, Kucherlapati RS, Chaganti RS (Nov 2002). "Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes". Cancer Res. 62 (21): 6218–23. PMID   12414650.
6. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
7. "Entrez Gene: GOLT1B golgi transport 1 homolog B (S. cerevisiae)".
8. Connerly, PL (2010). "How Do Proteins Move Through the Golgi Apparatus?". Nature Education. 3 (9): 60.
9. Conchon S, Cao X, Barlowe C, Pelham HR (July 1999). "Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex". The EMBO Journal. 18 (14): 3934–46. doi:10.1093/emboj/18.14.3934. PMC   1171469 . PMID   10406798.

Further reading

• Conchon S, Cao X, Barlowe C, Pelham HR (July 1999). "Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex". The EMBO Journal. 18 (14): 3934–46. doi:10.1093/emboj/18.14.3934. PMC   1171469 . PMID   10406798.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID   12761501. S2CID   38880905.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.