GPA33

Last updated
GPA33
Identifiers
Aliases GPA33 , A33, glycoprotein A33
External IDs OMIM: 602171 MGI: 1891703 HomoloGene: 4245 GeneCards: GPA33
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005814

NM_021610
NM_001360925
NM_001360926

RefSeq (protein)

NP_005805

NP_067623
NP_001347854
NP_001347855

Location (UCSC) Chr 1: 167.05 – 167.17 Mb Chr 1: 165.96 – 165.99 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene. [5] [6] [7]

Contents

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [7]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143167 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000544 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW (Mar 1997). "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily". Proc Natl Acad Sci U S A. 94 (2): 469–74. Bibcode:1997PNAS...94..469H. doi: 10.1073/pnas.94.2.469 . PMC   19536 . PMID   9012807.
  6. Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium". Biochem Biophys Res Commun. 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID   9245713.
  7. 1 2 "Entrez Gene: GPA33 glycoprotein A33 (transmembrane)".

Further reading