GPLD1

Last updated
GPLD1
Identifiers
Aliases GPLD1 , GPIPLD, GPIPLDM, PIGPLD, PIPLD, glycosylphosphatidylinositol specific phospholipase D1
External IDs OMIM: 602515; MGI: 106604; HomoloGene: 1152; GeneCards: GPLD1; OMA:GPLD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001503
NM_177483

NM_008156

RefSeq (protein)

NP_001494

n/a

Location (UCSC) Chr 6: 24.42 – 24.5 Mb Chr 13: 25.13 – 25.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol-glycan-specific phospholipase D is an enzyme that in humans is encoded by the GPLD1 gene. [5] [6]

Contents

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by the GPLD1 gene is a GPI degrading enzyme that hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [6]

Plasma concentrations of Gpld1 in mice were found to increase after exercise and to correlate with improved cognitive function, and concentrations of GPLD1 in blood were increased in active elderly humans. [7] [8]

Interactions

GPLD1 has been shown to interact with Apolipoprotein A1 [9] and APOA4. [9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112293 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021340 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Schofield JN, Rademacher TW (November 2000). "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1494 (1–2): 189–94. doi:10.1016/s0167-4781(00)00194-9. PMID   11072085.
  6. 1 2 "Entrez Gene: GPLD1 glycosylphosphatidylinositol specific phospholipase D1".
  7. Horowitz AM, Fan X, Bieri G, Smith LK, Sanchez-Diaz CI, Schroer AB, et al. (July 2020). "Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain". Science. 369 (6500): 167–173. Bibcode:2020Sci...369..167H. doi:10.1126/science.aaw2622. PMC   7879650 . PMID   32646997. S2CID   220428681.
  8. Harris R (9 June 2020). "An Enzyme That Increases With Exercise Can Improve Memory In Mice, And Maybe People". National Public Radio .
  9. 1 2 Deeg MA, Bierman EL, Cheung MC (March 2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". Journal of Lipid Research. 42 (3): 442–51. doi: 10.1016/S0022-2275(20)31669-2 . PMID   11254757.

Further reading