GPM6B

GPM6B
Identifiers
Aliases	GPM6B , M6B, glycoprotein M6B
External IDs	OMIM: 300051 MGI: 107672 HomoloGene: 128189 GeneCards: GPM6B
Gene location (Human) Chr. X chromosome (human) [1] Band Xp22.2 Start 13,770,939 bp [1] End 13,938,638 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X F5 Start 165,021,907 bp [2] End 165,171,984 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus inferior ganglion of vagus nerve inferior olivary nucleus subthalamic nucleus Region I of hippocampus proper optic nerve postcentral gyrus ventral tegmental area pons superior vestibular nucleus Top expressed in olfactory tubercle cerebellar vermis optic nerve globus pallidus nucleus accumbens prefrontal cortex subiculum ventral tegmental area barrel cortex lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component integral component of membrane membrane raft plasma membrane membrane Biological process regulation of focal adhesion assembly protein transport multicellular organism development negative regulation of serotonin uptake cell differentiation negative regulation of protein localization to cell surface regulation of actin cytoskeleton organization extracellular matrix assembly ossification nervous system development positive regulation of bone mineralization neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2824 14758 Ensembl ENSG00000046653 ENSMUSG00000031342 UniProt Q13491 P35803 RefSeq (mRNA) NM_001001994 NM_001001995 NM_001001996 NM_005278 NM_001318729 NM_001177955 NM_001177956 NM_001177957 NM_001177958 NM_001177959 NM_001177960 NM_001177961 NM_001177962 NM_023122 RefSeq (protein) NP_001001994 NP_001001995 NP_001001996 NP_001305658 NP_005269 NP_001171426 NP_001171427 NP_001171428 NP_001171429 NP_001171430 NP_001171431 NP_001171432 NP_001171433 NP_075611 Location (UCSC) Chr X: 13.77 – 13.94 Mb Chr X: 165.02 – 165.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal membrane glycoprotein M6-b is a protein that in humans is encoded by the GPM6B gene. ^{[5] [6]}

In melanocytic cells, GPM6B gene expression may be regulated by MITF. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000046653 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031342 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger SL, Yan Y, Lagenaur C, Narayanan V (Sep 1996). "Chromosomal mapping of the human M6 genes". Genomics. 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID   8661015.
6. "Entrez Gene: GPM6B glycoprotein M6B".
7. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971.

Further reading

• Yan Y, Lagenaur C, Narayanan V (1993). "Molecular cloning of M6: identification of a PLP/DM20 gene family". Neuron. 11 (3): 423–31. doi:10.1016/0896-6273(93)90147-J. PMID   8398137. S2CID   46719251.
• Narayanan V, Olinsky S, Dahle E, et al. (1998). "Mutation analysis of the M6b gene in patients with Rett syndrome". Am. J. Med. Genet. 78 (2): 165–8. doi:10.1002/(SICI)1096-8628(19980630)78:2<165::AID-AJMG13>3.0.CO;2-L. PMID   9674909.
• Yoshida M, Shan WS, Colman DR (1999). "Conserved and divergent expression patterns of the proteolipid protein gene family in the amphibian central nervous system". J. Neurosci. Res. 57 (1): 13–22. doi:10.1002/(SICI)1097-4547(19990701)57:1<13::AID-JNR2>3.0.CO;2-E. PMID   10397631. S2CID   28005024.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Werner H, Dimou L, Klugmann M, et al. (2002). "Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes". Mol. Cell. Neurosci. 18 (6): 593–605. doi:10.1006/mcne.2001.1044. PMID   11749036. S2CID   24468488.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Henneke M, Wehner LE, Hennies HC, et al. (2005). "Mutation analysis of the M6b gene in patients with Pelizaeus-Merzbacher-like syndrome". Am. J. Med. Genet. A. 128 (2): 156–8. doi:10.1002/ajmg.a.30068. PMID   15214007. S2CID   83895622.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.