GPSM1

GPSM1
Identifiers
Aliases	GPSM1 , AGS3, G-protein signaling modulator 1, G protein signaling modulator 1
External IDs	OMIM: 609491 MGI: 1915089 HomoloGene: 16987 GeneCards: GPSM1
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.3 Start 136,327,476 bp [1] End 136,359,605 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A3 Start 26,205,527 bp [2] End 26,238,249 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia retinal pigment epithelium ganglionic eminence cerebellar vermis sural nerve middle temporal gyrus amniotic fluid stromal cell of endometrium endothelial cell corpus epididymis Top expressed in saccule barrel cortex cerebellar cortex olfactory bulb atrioventricular valve fossa otic placode substantia nigra aortic valve motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase regulator activity GDP-dissociation inhibitor activity Cellular component cytoplasm cytosol Golgi apparatus endoplasmic reticulum membrane Golgi membrane endoplasmic reticulum membrane plasma membrane cell cortex protein-containing complex Biological process multicellular organism development cell differentiation nervous system development positive regulation of macroautophagy negative regulation of GTPase activity negative regulation of guanyl-nucleotide exchange factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26086 67839 Ensembl ENSG00000160360 ENSMUSG00000026930 UniProt Q86YR5 Q6IR34 RefSeq (mRNA) NM_001145638 NM_001145639 NM_001200003 NM_015597 NM_001199146 NM_001199147 NM_153410 NM_001355574 NM_001355575 NM_001355576 RefSeq (protein) NP_001139110 NP_001139111 NP_001186932 NP_056412 NP_001186075 NP_001186076 NP_700459 NP_001342503 NP_001342504 NP_001342505 Location (UCSC) Chr 9: 136.33 – 136.36 Mb Chr 2: 26.21 – 26.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene. ^{[5] [6] [7]}

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000160360 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026930 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pizzinat N, Takesono A, Lanier SM (May 2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains". J Biol Chem. 276 (20): 16601–10. doi: 10.1074/jbc.M007573200 . PMID   11278352.
6. Peterson YK, Bernard ML, Ma H, Hazard S III, Graber SG, Lanier SM (Nov 2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3". J Biol Chem. 275 (43): 33193–6. doi: 10.1074/jbc.C000509200 . PMID   10969064.
7. "Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans)".

Further reading

• Natochin M, Lester B, Peterson YK, et al. (2001). "AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin". J. Biol. Chem. 275 (52): 40981–5. doi: 10.1074/jbc.M006478200 . PMID   11024022.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Pattingre S, De Vries L, Bauvy C, et al. (2003). "The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells". J. Biol. Chem. 278 (23): 20995–1002. doi: 10.1074/jbc.M300917200 . PMID   12642577.
• Kaushik R, Yu F, Chia W, et al. (2004). "Subcellular Localization of LGN During Mitosis: Evidence for Its Cortical Localization in Mitotic Cell Culture Systems and Its Requirement for Normal Cell Cycle Progression". Mol. Biol. Cell. 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMC   181556 . PMID   12925752.
• Adhikari A, Sprang SR (2004). "Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1". J. Biol. Chem. 278 (51): 51825–32. doi: 10.1074/jbc.M306300200 . PMID   14530282.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell. 119 (4): 503–16. doi: 10.1016/j.cell.2004.10.028 . PMID   15537540. S2CID   12900159.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID   16458856.