GRAFS

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The GPCR superfamily is the largest gene family in the human genome containing approximately 800 genes. [1] As the vertebrate superfamily can be phylogenetically grouped into five main families the GRAFS classification system has been proposed.

GRAFS stands for Glutamate, Rhodopsin, Adhesion, Frizzled/Taste2, Secretin. [2] They correspond to classical classes C (class C, glutamate), A (rhodopsin-like), B2 (Secretin receptor family, long N-terminal), F (Frizzled/Smoothened), and B1+3 (other secretin). [3] Taste2 has more recently considered to be closer to Rhodopsin-like receptors. [4]

See also

References

  1. ↑ Lander, ES; Linton, LM; Birren; International Human Genome Sequencing, Consortium; et al. (Feb 15, 2001). "Initial sequencing and analysis of the human genome" (PDF). Nature. 409 (6822): 860–921. Bibcode:2001Natur.409..860L. doi: 10.1038/35057062 . PMID   11237011.
  2. ↑ Fredriksson, R; Lagerström, MC; Lundin, LG; Schiöth, HB (June 2003). "The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints". Molecular Pharmacology. 63 (6): 1256–72. doi:10.1124/mol.63.6.1256. PMID   12761335.
  3. ↑ Krishnan, A; Almén, MS; Fredriksson, R; Schiöth, HB (2012). "The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi". PLOS ONE. 7 (1) e29817. Bibcode:2012PLoSO...729817K. doi: 10.1371/journal.pone.0029817 . PMC   3251606 . PMID   22238661.
  4. ↑ Nordström KJ, Sällman Almén M, Edstam MM, Fredriksson R, Schiöth HB (September 2011). "Independent HHsearch, Needleman—Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families". Molecular Biology and Evolution. 28 (9): 2471–80. doi: 10.1093/molbev/msr061 . PMID   21402729.


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