GREB1

GREB1
Identifiers
Aliases	GREB1 , growth regulation by estrogen in breast cancer 1, growth regulating estrogen receptor binding 1
External IDs	OMIM: 611736; MGI: 2149712; HomoloGene: 8780; GeneCards: GREB1; OMA:GREB1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	11,642,788 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	16,850,887 bp
RNA expression pattern
	Top expressed in
	left ovary; ; right ovary; ; germinal epithelium; ; canal of the cervix; ; left uterine tube; ; myometrium; ; body of uterus; ; right uterine tube; ; prostate; ; ectocervix;
	Top expressed in
	tail of embryo; ; cumulus cell; ; lumbar spinal ganglion; ; efferent ductule; ; primitive streak; ; otic vesicle; ; adrenal gland; ; substantia nigra; ; Paneth cell; ; ovary;
	More reference expression data
	n/a
Orthologs
	9687
	268527
	ENSG00000196208
	ENSMUSG00000036523
	Q4ZG55
	Q3UHK3
	NM_014668 ; NM_033090 ; NM_148903
	NM_001252071 ; NM_015764
	NP_055483 ; NP_149081 ; NP_683701
	NP_001239000 ; NP_056579
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 19, 2025

Growth regulation by estrogen in breast cancer 1 is a protein that in humans is encoded by the GREB1 gene.^[5]

Function

This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196208 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036523 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Growth regulation by estrogen in breast cancer 1".

Hnatyszyn HJ, Liu M, Hilger A, Herbert L, Gomez-Fernandez CR, Jorda M, Thomas D, Rae JM, El-Ashry D, Lippman ME (2010). "Correlation of GREB1 mRNA with protein expression in breast cancer: Validation of a novel GREB1 monoclonal antibody". Breast Cancer Research and Treatment. 122 (2): 371–80. doi:10.1007/s10549-009-0584-x. PMID 19842031. S2CID 22189668.
Deschênes J, Bourdeau V, White JH, Mader S (2007). "Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences". Journal of Biological Chemistry. 282 (24): 17335–9. doi: 10.1074/jbc.C700030200 . PMID 17463000.
Chand AL, Wijayakumara DD, Knower KC, Herridge KA, Howard TL, Lazarus KA, Clyne CD (2012). "The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation". PLOS ONE. 7 (2) e31593. Bibcode:2012PLoSO...731593C. doi: 10.1371/journal.pone.0031593 . PMC 3281101 . PMID 22359603.
Pellegrini C, Gori I, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, Canny GO (2012). "The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis". Fertility and Sterility. 98 (5): 1200–8. doi: 10.1016/j.fertnstert.2012.06.056 . PMID 22884659.
Liu M, Wang G, Gomez-Fernandez CR, Guo S (2012). "GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer". PLOS ONE. 7 (10) e46410. Bibcode:2012PLoSO...746410L. doi: 10.1371/journal.pone.0046410 . PMC 3463574 . PMID 23056300.
Nyholt DR, Low SK, Anderson CA, Painter JN, Uno S, Morris AP, MacGregor S, Gordon SD, Henders AK, Martin NG, Attia J, Holliday EG, McEvoy M, Scott RJ, Kennedy SH, Treloar SA, Missmer SA, Adachi S, Tanaka K, Nakamura Y, Zondervan KT, Zembutsu H, Montgomery GW (2012). "Genome-wide association meta-analysis identifies new endometriosis risk loci" (PDF). Nature Genetics. 44 (12): 1355–9. doi:10.1038/ng.2445. PMC 3527416 . PMID 23104006.
Rae JM, Johnson MD, Cordero KE, Scheys JO, Larios JM, Gottardis MM, Pienta KJ, Lippman ME (2006). "GREB1 is a novel androgen-regulated gene required for prostate cancer growth". The Prostate. 66 (8): 886–94. doi:10.1002/pros.20403. hdl: 2027.42/49275 . PMID 16496412. S2CID 24744169.
Rittié L, Kang S, Voorhees JJ, Fisher GJ (2008). "Induction of collagen by estradiol: Difference between sun-protected and photodamaged human skin in vivo". Archives of Dermatology. 144 (9): 1129–40. doi: 10.1001/archderm.144.9.1129 . PMID 18794456.
Ghosh MG, Thompson DA, Weigel RJ (2000). "PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer". Cancer Research. 60 (22): 6367–75. PMID 11103799.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196208 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036523 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: Growth regulation by estrogen in breast cancer 1".

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GREB1

Contents

Function

References

Further reading