GRIP2

GRIP2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1V62, 1X5R
Identifiers
Aliases	GRIP2 , glutamate receptor interacting protein 2
External IDs	MGI: 2681173; HomoloGene: 16327; GeneCards: GRIP2; OMA:GRIP2 - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse) [1] Band 6|6 D1 Start 91,738,490 bp [1] End 91,804,231 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of tongue left ventricle gastrocnemius muscle thoracic diaphragm triceps brachii muscle vastus lateralis muscle ventral tegmental area cardia right ventricle subthalamic nucleus Top expressed in aortic valve ascending aorta substantia nigra ventral tegmental area lumbar subsegment of spinal cord habenula dorsal tegmental nucleus superior colliculus decidua olfactory bulb More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor complex adaptor activity Cellular component cytoplasm cytosol plasma membrane membrane postsynaptic density dendrite postsynaptic membrane glutamatergic synapse Biological process Notch signaling pathway positive regulation of signal transduction artery smooth muscle contraction protein transport positive regulation of blood pressure neurotransmitter receptor transport, endosome to postsynaptic membrane vesicle-mediated transport in synapse Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80852 243547 Ensembl n/a ENSMUSG00000030098 UniProt Q9C0E4 n/a RefSeq (mRNA) NM_001080423 NM_001033353 NM_001159507 RefSeq (protein) NP_001073892 n/a Location (UCSC) n/a Chr 6: 91.74 – 91.8 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Glutamate receptor-interacting protein 2 is a protein that in humans is encoded by the GRIP2 gene. ^[4]

Interactions

GRIP2 has been shown to interact with liprin-alpha-1. ^{[5] [6]}

References

1. GRCm38: Ensembl release 89: ENSMUSG00000030098 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: GRIP2 glutamate receptor interacting protein 2".
5. Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID   12923177.
6. Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi: 10.1523/JNEUROSCI.23-05-01667.2003 . PMC   6741975 . PMID   12629171.

Further reading

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• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Srivastava S, Osten P, Vilim FS, Khatri L, Inman G, States B, Daly C, DeSouza S, Abagyan R, Valtschanoff JG, Weinberg RJ, Ziff EB (1998). "Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP". Neuron. 21 (3): 581–91. doi: 10.1016/S0896-6273(00)80568-1 . PMID   9768844. S2CID   14448034.
• Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD (1999). "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands". Neuron. 21 (6): 1453–63. doi: 10.1016/S0896-6273(00)80663-7 . PMID   9883737. S2CID   15441813.
• Brückner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R (1999). "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains". Neuron. 22 (3): 511–24. doi: 10.1016/S0896-6273(00)80706-0 . PMID   10197531.
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
• Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi: 10.1016/S0896-6273(00)81198-8 . PMID   10896157. S2CID   16571878.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID   11214970.
• Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi: 10.1093/dnares/7.6.357 . PMID   11214971.
• Lin SH, Arai AC, Wang Z, Nothacker HP, Civelli O (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. doi:10.1124/mol.60.5.916. PMID   11641419.
• Stegmüller J, Werner H, Nave KA, Trotter J (2003). "The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling". J. Biol. Chem. 278 (6): 3590–8. doi: 10.1074/jbc.M210010200 . PMID   12458226.
• Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi: 10.1074/jbc.M307561200 . PMID   12923177.