GRIPAP1

GRIPAP1
Identifiers
Aliases	GRIPAP1 , GRASP-1, GRIP1 associated protein 1
External IDs	OMIM: 300408 MGI: 1859616 HomoloGene: 41348 GeneCards: GRIPAP1
Gene location (Human)
Chr.	X chromosome (human)
End	49,002,264 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	7,686,806 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; anterior pituitary; ; cingulate gyrus; ; Brodmann area 9; ; prefrontal cortex; ; hypothalamus; ; nucleus accumbens; ; right uterine tube; ; right lobe of thyroid gland; ; putamen;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; yolk sac; ; olfactory bulb; ; thymus; ; nucleus accumbens; ; spleen; ; Region I of hippocampus proper; ; pituitary gland; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; molecular function ;
Cellular component	endosome ; blood microparticle ; nucleoplasm ; cytosol ; intracellular membrane-bounded organelle ; postsynaptic recycling endosome ; membrane ; cell junction ; axon ; dendrite ; early endosome membrane ; cell projection ; synapse ; recycling endosome membrane ; glutamatergic synapse ; extrinsic component of postsynaptic early endosome membrane ;
Biological process	neurotransmitter receptor transport, endosome to postsynaptic membrane ; regulation of modification of synaptic structure ; transport ; protein transport ; biological process ; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane ; regulation of recycling endosome localization within postsynapse ;
	Sources:Amigo / QuickGO
Orthologs
	56850
	54645
	ENSG00000068400
	ENSMUSG00000031153
	Q4V328
	Q8VD04
	NM_020137 ; NM_207672
NM_001290455 ; NM_207670 ; NM_001359289 ; NM_001359290 ; NM_001359291 ;
	NM_001359293
	NP_064522
NP_001277384 ; NP_997553 ; NP_001346218 ; NP_001346219 ; NP_001346220 ;
	NP_001346222
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 14, 2024

GRIP1-associated protein 1 is a protein that in humans is encoded by the GRIPAP1 gene.^[5]^[6]

Function

GRASP1 is a neuron-specific guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) and is associated with the GRIP/AMPA receptor complex in brain (Ye et al., 2000).[supplied by OMIM]^[6]

Interactions

GRIPAP1 has been shown to interact with GRIP1.^[5]

Related Research Articles

The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals. Proteins containing PDZ domains play a key role in anchoring receptor proteins in the membrane to cytoskeletal components. Proteins with these domains help hold together and organize signaling complexes at cellular membranes. These domains play a key role in the formation and function of signal transduction complexes. PDZ domains also play a highly significant role in the anchoring of cell surface receptors to the actin cytoskeleton via mediators like NHERF and ezrin.

Erbb2 interacting protein (ERBB2IP), also known as erbin, is a protein which in humans is encoded by the ERBB2IP gene. Discovered in 1997, erbin is a 200kDa protein containing a PDZ domain.

Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene.

Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene. DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Syntenin-1 is a protein that in humans is encoded by the SDCBP gene.

Glutamate ionotropic receptor AMPA type subunit 2 is a protein that in humans is encoded by the GRIA2 gene and it is a subunit found in the AMPA receptors.

Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene.

Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein that in humans is encoded by the GRIK1 gene.

Glutamate receptor 4 is a protein that in humans is encoded by the GRIA4 gene.

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. This protein is also called RhoGEF11 or PDZ-RhoGEF.

Band 4.1-like protein 1 is a protein that in humans is encoded by the EPB41L1 gene.

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. This protein is also called RhoGEF12 or Leukemia-associated Rho guanine nucleotide exchange factor (LARG).

Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded by the SYNGAP1 gene. SYNGAP1 is a ras GTPase-activating protein that is critical for the development of cognition and proper synapse function. Mutations in humans can cause intellectual disability, epilepsy, autism and sensory processing deficits.

Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene.

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.

Glutamate receptor-interacting protein 2 is a protein that in humans is encoded by the GRIP2 gene.

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene.

Glutamate receptor-interacting protein (GRIP) refers to either a family of proteins that bind to the glutamate receptor or specifically to the GRIP1 protein within this family. Proteins in the glutamate receptor-interacting protein (GRIP) family have been shown to interact with GluR2, a common subunit in the AMPA receptor. This subunit also interacts with other proteins such as protein interacting with C-kinase1 (PICK1) and N-ethylmaleimide-sensitive fusion protein (NSF). Studies have begun to elucidate its function; however, much is still to be learned about these proteins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000068400 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031153 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (Aug 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi: 10.1016/S0896-6273(00)81198-8 . PMID 10896157.
1 2 "Entrez Gene: GRIPAP1 GRIP1 associated protein 1".

Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID 10574461.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP (2002). "Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex". J. Biol. Chem. 277 (4): 2396–405. doi: 10.1074/jbc.M106312200 . PMID 11704662.
Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi: 10.1074/jbc.C200112200 . hdl: 2262/89271 . PMID 11891216.
Ye B, Sugo N, Hurn PD, Huganir RL (2002). "Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody". Neuroscience. 114 (1): 217–27. doi:10.1016/S0306-4522(02)00142-2. PMID 12207967. S2CID 39432674.
Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906. doi: 10.1242/jcs.00278 . PMID 12571287.
Nakata A, Ito T, Nagata M, Hori S, Sekimizu K (2004). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1". Genes Cells. 9 (11): 1125–35. doi: 10.1111/j.1365-2443.2004.00795.x . PMID 15507123.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Stinton LM, Selak S, Fritzler MJ (2005). "Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes". Clin. Immunol. 116 (2): 108–17. doi:10.1016/j.clim.2005.03.021. PMID 15897011.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000068400 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031153 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10896157-5] 1 2 Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (Aug 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi: 10.1016/S0896-6273(00)81198-8 . PMID 10896157.

[entrez-6] 1 2 "Entrez Gene: GRIPAP1 GRIP1 associated protein 1".

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GRIPAP1

Contents

Function

Interactions

Related Research Articles

References

Further reading