GSTA4

Last updated
GSTA4
Protein GSTA4 PDB 1gul.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases GSTA4 , GSTA4-4, GTA4, glutathione S-transferase alpha 4
External IDs OMIM: 605450 HomoloGene: 55585 GeneCards: GSTA4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001512

n/a

RefSeq (protein)

NP_001503

n/a

Location (UCSC) Chr 6: 52.98 – 53 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Glutathione S-transferase A4, also known as GSTA4, is an enzyme which in humans is encoded by the GSTA4 gene. [3] [4] [5]

Contents

Function

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. [3]

GSTA4 shows very high activity with reactive carbonyl compounds such as alk-2-enals. [4] GSTA4 is highly effective in catalyzing the conjugate addition of reduced glutathione to 4-hydroxynonenal, an important product of peroxidative degradation of arachidonic acid and a commonly used biomarker for oxidative damage in tissue. [5]

Clinical significance

Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis hence reduced expression of the GSTA4 enzyme may have pathophysiological consequences. [3] The expression of this gene is decreased drastically among burn and trauma victims.[ citation needed ]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170899 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. 1 2 3 "Entrez Gene: GSTA4 glutathione S-transferase A4".
  4. 1 2 Board PG (March 1998). "Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4". Biochem. J. 330 (Pt 2): 827–31. doi:10.1042/bj3300827. PMC   1219212 . PMID   9480897.
  5. 1 2 Hubatsch I, Ridderström M, Mannervik B (February 1998). "Human glutathione transferase A4-4: an alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation". Biochem. J. 330 (Pt 1): 175–9. doi:10.1042/bj3300175. PMC   1219124 . PMID   9461507.

Further reading