GSTM3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | GSTM3 , GST5, GSTB, GSTM3-3, GTM3, glutathione S-transferase mu 3 (brain), glutathione S-transferase mu 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 138390 MGI: 1309466 HomoloGene: 658 GeneCards: GSTM3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Glutathione S-transferase M3 (brain), also known as GSTM2, is an enzyme which in humans is encoded by the GSTM99
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including some carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. [5]
Glutathione S-transferases (GSTs), previously known as ligandins, are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies: the cytosolic, mitochondrial, and microsomal—also known as MAPEG—proteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new GST functions.
Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene.
Glutathione S-transferase Mu 1 is a human glutathione S-transferase.
Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene.
Glutathione S-transferase A1 is an enzyme that in humans is encoded by the GSTA1 gene.
Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene. Gamma-enolase is a phosphopyruvate hydratase.
Glutathione S-transferase A2 is an enzyme that in humans is encoded by the GSTA2 gene.
Alcohol dehydrogenase class-3 is an enzyme that in humans is encoded by the ADH5 gene.
Glutathione S-transferase Mu 2 is an enzyme that in humans is encoded by the GSTM2 gene.
Glutathione S-transferase A4, also known as GSTA4, is an enzyme which in humans is encoded by the GSTA4 gene.
Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene.
Glutathione S-transferase Mu 4 is an enzyme that in humans is encoded by the GSTM4 gene.
Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the MGST1 gene.
Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.
PGDS protein is a protein that in humans is encoded by the HPGDS gene.
Glutathione S-transferase A3 is an enzyme that in humans is encoded by the GSTA3 gene.
Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene.
Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.
Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.
Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene.