GSTO1

Last updated

GSTO1
Protein GSTO1 PDB 1eem.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSTO1 , GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1
External IDs OMIM: 605482; MGI: 1342273; HomoloGene: 37971; GeneCards: GSTO1; OMA:GSTO1 - orthologs
EC number 1.20.4.2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004832
NM_001191002
NM_001191003

NM_010362

RefSeq (protein)

NP_001177931
NP_001177932
NP_004823

NP_034492

Location (UCSC) Chr 10: 104.24 – 104.27 Mb Chr 19: 47.84 – 47.85 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene. [5] [6] [7]

This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis. [7] This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000148834 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025068 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, et al. (Sep 2000). "Identification, characterization, and crystal structure of the Omega class glutathione transferases". J Biol Chem. 275 (32): 24798–806. doi: 10.1074/jbc.M001706200 . PMID   10783391.
  6. Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics. 13 (3): 131–44. doi:10.1097/00008571-200303000-00003. PMID   12618591.
  7. 1 2 "Entrez Gene: GSTO1 glutathione S-transferase omega 1".
  8. Whitbread AK, Masoumi A, Tetlow N, Schmuck E, Coggan M, Board PG (2005). "Characterization of the Omega Class of Glutathione Transferases". Gluthione Transferases and Gamma-Glutamyl Transpeptidases. Methods in Enzymology. Vol. 401. pp.  78–99. doi:10.1016/S0076-6879(05)01005-0. ISBN   978-0-12-182806-6. PMID   16399380.

Further reading