GTF2A1L

GTF2A1L
Identifiers
Aliases	GTF2A1L , ALF, general transcription factor IIA subunit 1 like
External IDs	OMIM: 605358 MGI: 1919078 HomoloGene: 86732 GeneCards: GTF2A1L
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	89,022,580 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; left uterine tube; ; Achilles tendon; ; canal of the cervix; ; right lung; ; popliteal artery; ; myometrium; ; ascending aorta; ; left coronary artery; ; gastric mucosa;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; secondary oocyte; ; medial ganglionic eminence; ; blastocyst; ; islet of Langerhans; ; knee joint; ; ureter; ; exocrine gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding ; transcription coactivator activity ; protein binding ;
Cellular component	transcription factor TFIIA complex ; nucleus ; cytoplasm ;
Biological process	transcription initiation from RNA polymerase II promoter ; regulation of transcription, DNA-templated ; transcription by RNA polymerase II ; cognition ; transcription, DNA-templated ; positive regulation of nucleic acid-templated transcription ;
	Sources:Amigo / QuickGO
Orthologs
	11036
	71828
	n/a
	ENSMUSG00000024154
	Q9UNN4
	Q8R4I4
	NM_172196 ; NM_001193487 ; NM_006872
	NM_023630
	NP_001180416 ; NP_006863
	NP_076119
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene.^[4]^[5]^[6]^[7]

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA.

This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified.

Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.^[7]

Related Research Articles

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.

Transcription factor TF_IIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. TF_IIA is one of several general (basal) transcription factors (GTFs) that are required for all transcription events that use RNA polymerase II. Other GTFs include TF_IID, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TF_IIB, TF_IIE, TF_IIF, and TF_IIH. Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template.

C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

Serum response factor, also known as SRF, is a transcription factor protein.

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.

Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.

Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

Transcription initiation factor TFIID subunit 8 is a protein that in humans is encoded by the TAF8 gene.

Vinexin is a protein that in humans is encoded by the SORBS3 gene.

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.

Transcription factor RFX4 is a protein that in humans is encoded by the RFX4 gene.

snRNA-activating protein complex subunit 1 is a protein that in humans is encoded by the SNAPC1 gene.

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.

Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024154 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Upadhyaya AB, Lee SH, DeJong J (Jul 1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis". J Biol Chem. 274 (25): 18040–8. doi: 10.1074/jbc.274.25.18040 . PMID 10364255.
↑ Xie W, Han S, Khan M, DeJong J (May 2002). "Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation". J Biol Chem. 277 (20): 17765–74. doi: 10.1074/jbc.M200954200 . PMID 11889132.
↑ Huang M, Wang H, Li J, Zhou Z, Du Y, Lin M, Sha J (Mar 2006). "Involvement of ALF in human spermatogenesis and male infertility". Int J Mol Med. 17 (4): 599–604. doi: 10.3892/ijmm.17.4.599 . PMID 16525715.
1 2 "Entrez Gene: ALF TFIIA-alpha/beta-like factor".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Loveys DA, Streiff MB, Kato GJ (1996). "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein". Nucleic Acids Res. 24 (14): 2813–20. doi:10.1093/nar/24.14.2813. PMC 145994 . PMID 8759016.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode:1998PNAS...95.2192M. doi: 10.1073/pnas.95.5.2192 . PMC 19292 . PMID 9482861.
Han SY, Zhou L, Upadhyaya A, et al. (2001). "TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse". Biol. Reprod. 64 (2): 507–17. doi: 10.1095/biolreprod64.2.507 . PMID 11159353.
Yoshida S, Ohbo K, Takakura A, et al. (2002). "Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice". Dev. Biol. 240 (2): 517–30. doi: 10.1006/dbio.2001.0473 . PMID 11784080.
Upadhyaya AB, Khan M, Mou TC, et al. (2002). "The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex". J. Biol. Chem. 277 (37): 34208–16. doi: 10.1074/jbc.M204808200 . PMID 12107178.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Howe ML, Mehmud ZF, Saha S, et al. (2006). "Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo". Stem Cells Dev. 15 (2): 175–90. doi:10.1089/scd.2006.15.175. PMID 16646664.
Kim M, Li D, Cui Y, et al. (2006). "Regulatory factor interactions and somatic silencing of the germ cell-specific ALF gene". J. Biol. Chem. 281 (45): 34288–98. doi: 10.1074/jbc.M607168200 . PMID 16966320.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024154 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10364255-4] Upadhyaya AB, Lee SH, DeJong J (Jul 1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis". J Biol Chem. 274 (25): 18040–8. doi: 10.1074/jbc.274.25.18040 . PMID 10364255.

[pmid11889132-5] Xie W, Han S, Khan M, DeJong J (May 2002). "Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation". J Biol Chem. 277 (20): 17765–74. doi: 10.1074/jbc.M200954200 . PMID 11889132.

[pmid16525715-6] Huang M, Wang H, Li J, Zhou Z, Du Y, Lin M, Sha J (Mar 2006). "Involvement of ALF in human spermatogenesis and male infertility". Int J Mol Med. 17 (4): 599–604. doi: 10.3892/ijmm.17.4.599 . PMID 16525715.

[entrez-7] 1 2 "Entrez Gene: ALF TFIIA-alpha/beta-like factor".

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[3]

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[7]

GTF2A1L

Related Research Articles

References

Further reading