GTF2A1L

GTF2A1L
Identifiers
Aliases	GTF2A1L , ALF, general transcription factor IIA subunit 1 like
External IDs	OMIM: 605358; MGI: 1919078; GeneCards: GTF2A1L
Gene location (Mouse) Chr. Chromosome 17 (mouse) [1] Band 17|17 E4 Start 88,976,088 bp [1] End 89,022,580 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium left uterine tube Achilles tendon canal of the cervix right lung popliteal artery myometrium ascending aorta left coronary artery gastric mucosa Top expressed in seminiferous tubule spermatid spermatocyte primary oocyte secondary oocyte zygote embryo embryo blastocyst medial ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding transcription coactivator activity protein binding Cellular component transcription factor TFIIA complex nucleus cytoplasm Biological process transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II cognition transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry Species Human Mouse Entrez 11036 71828 Ensembl n/a ENSMUSG00000024154 UniProt Q9UNN4 Q8R4I4 RefSeq (mRNA) NM_172196 NM_001193487 NM_006872 NM_023630 RefSeq (protein) NP_001180416 NP_006863 NP_076119 Location (UCSC) n/a Chr 17: 88.98 – 89.02 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene. ^{[4] [5] [6] [7]}

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA.

This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified.

Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product. ^[7]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000024154 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Upadhyaya AB, Lee SH, DeJong J (Jul 1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis". J Biol Chem. 274 (25): 18040–8. doi: 10.1074/jbc.274.25.18040 . PMID   10364255.
5. Xie W, Han S, Khan M, DeJong J (May 2002). "Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation". J Biol Chem. 277 (20): 17765–74. doi: 10.1074/jbc.M200954200 . PMID   11889132.
6. Huang M, Wang H, Li J, Zhou Z, Du Y, Lin M, Sha J (Mar 2006). "Involvement of ALF in human spermatogenesis and male infertility". Int J Mol Med. 17 (4): 599–604. doi: 10.3892/ijmm.17.4.599 . PMID   16525715.
7. "Entrez Gene: ALF TFIIA-alpha/beta-like factor".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Loveys DA, Streiff MB, Kato GJ (1996). "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein". Nucleic Acids Res. 24 (14): 2813–20. doi:10.1093/nar/24.14.2813. PMC   145994 . PMID   8759016.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode:1998PNAS...95.2192M. doi: 10.1073/pnas.95.5.2192 . PMC   19292 . PMID   9482861.
• Han SY, Zhou L, Upadhyaya A, et al. (2001). "TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse". Biol. Reprod. 64 (2): 507–17. doi: 10.1095/biolreprod64.2.507 . PMID   11159353.
• Yoshida S, Ohbo K, Takakura A, et al. (2002). "Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice". Dev. Biol. 240 (2): 517–30. doi: 10.1006/dbio.2001.0473 . PMID   11784080.
• Upadhyaya AB, Khan M, Mou TC, et al. (2002). "The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex". J. Biol. Chem. 277 (37): 34208–16. doi: 10.1074/jbc.M204808200 . PMID   12107178.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Howe ML, Mehmud ZF, Saha S, et al. (2006). "Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo". Stem Cells Dev. 15 (2): 175–90. doi:10.1089/scd.2006.15.175. PMID   16646664.
• Kim M, Li D, Cui Y, et al. (2006). "Regulatory factor interactions and somatic silencing of the germ cell-specific ALF gene". J. Biol. Chem. 281 (45): 34288–98. doi: 10.1074/jbc.M607168200 . PMID   16966320.