GTPBP1

GTPBP1
Identifiers
Aliases	GTPBP1 , GP-1, GP1, HSPC018, GTP binding protein 1
External IDs	OMIM: 602245; MGI: 109443; HomoloGene: 3165; GeneCards: GTPBP1; OMA:GTPBP1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.1 Start 38,705,742 bp [1] End 38,738,299 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E1 Start 79,575,046 bp [2] End 79,605,680 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastric mucosa ventricular zone ganglionic eminence right uterine tube left lobe of thyroid gland skin of leg popliteal artery tibial arteries left ovary Top expressed in neural layer of retina granulocyte dentate gyrus of hippocampal formation granule cell lip ventricular zone thymus secondary oocyte fetal liver hematopoietic progenitor cell zygote molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding RNA binding GTPase activity translation elongation factor activity Cellular component cytoplasm cytoplasmic exosome (RNase complex) cytosol membrane Biological process positive regulation of mRNA catabolic process immune response signal transduction GTP metabolic process translational elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9567 14904 Ensembl ENSG00000100226 ENSMUSG00000042535 UniProt O00178 O08582 RefSeq (mRNA) NM_004286 NM_013818 RefSeq (protein) NP_004277 NP_038846 Location (UCSC) Chr 22: 38.71 – 38.74 Mb Chr 15: 79.58 – 79.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene. ^{[5] [6]}

This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mice, where disruption of the gene for that protein had no observable phenotype. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000100226 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042535 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Senju S, Nishimura Y (Apr 1997). "Identification of human and mouse GP-1, a putative member of a novel G-protein family". Biochem Biophys Res Commun. 231 (2): 360–4. doi:10.1006/bbrc.1997.6103. PMID   9070279.
6. "Entrez Gene: GTPBP1 GTP binding protein 1".

Further reading

• Goretzki L, Mueller BM (1999). "Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein". Biochem. J. 336 (2): 381–6. doi:10.1042/bj3360381. PMC   1219882 . PMID   9820815.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Kudo H, Senju S, Mitsuya H, Nishimura Y (2000). "Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase". Biochem. Biophys. Res. Commun. 272 (2): 456–65. doi:10.1006/bbrc.2000.2763. PMID   10833435.
• Senju S, Iyama K, Kudo H, et al. (2000). "Immunocytochemical analyses and targeted gene disruption of GTPBP1". Mol. Cell. Biol. 20 (17): 6195–200. doi:10.1128/MCB.20.17.6195-6200.2000. PMC   86094 . PMID   10938096.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.