GTPBP1

GTPBP1
Identifiers
Aliases	GTPBP1 , GP-1, GP1, HSPC018, GTP binding protein 1
External IDs	OMIM: 602245 MGI: 109443 HomoloGene: 3165 GeneCards: GTPBP1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,738,299 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,605,680 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; gastric mucosa; ; ganglionic eminence; ; right uterine tube; ; left lobe of thyroid gland; ; popliteal artery; ; right lung; ; right lobe of thyroid gland; ; upper lobe of left lung; ; skin of abdomen;
	Top expressed in
	lip; ; thymus; ; secondary oocyte; ; molar; ; superior frontal gyrus; ; yolk sac; ; cerebellar cortex; ; hair follicle; ; ganglionic eminence; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; GTP binding ; RNA binding ; GTPase activity ; translation elongation factor activity ;
Cellular component	cytoplasm ; cytoplasmic exosome (RNase complex) ; cytosol ; membrane ;
Biological process	positive regulation of mRNA catabolic process ; immune response ; signal transduction ; GTP metabolic process ; translational elongation ;
	Sources:Amigo / QuickGO
Orthologs
	9567
	14904
	ENSG00000100226
	ENSMUSG00000042535
	O00178
	O08582
	NM_004286
	NM_013818
	NP_004277
	NP_038846
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 02, 2023

GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene.^[5]^[6]

This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mice, where disruption of the gene for that protein had no observable phenotype.^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100226 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042535 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Senju S, Nishimura Y (Apr 1997). "Identification of human and mouse GP-1, a putative member of a novel G-protein family". Biochem Biophys Res Commun. 231 (2): 360–4. doi:10.1006/bbrc.1997.6103. PMID 9070279.
1 2 "Entrez Gene: GTPBP1 GTP binding protein 1".

Goretzki L, Mueller BM (1999). "Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein". Biochem. J. 336 (2): 381–6. doi:10.1042/bj3360381. PMC 1219882 . PMID 9820815.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Kudo H, Senju S, Mitsuya H, Nishimura Y (2000). "Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase". Biochem. Biophys. Res. Commun. 272 (2): 456–65. doi:10.1006/bbrc.2000.2763. PMID 10833435.
Senju S, Iyama K, Kudo H, et al. (2000). "Immunocytochemical analyses and targeted gene disruption of GTPBP1". Mol. Cell. Biol. 20 (17): 6195–200. doi:10.1128/MCB.20.17.6195-6200.2000. PMC 86094 . PMID 10938096.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934 . PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100226 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042535 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9070279-5] Senju S, Nishimura Y (Apr 1997). "Identification of human and mouse GP-1, a putative member of a novel G-protein family". Biochem Biophys Res Commun. 231 (2): 360–4. doi:10.1006/bbrc.1997.6103. PMID 9070279.

[entrez-6] 1 2 "Entrez Gene: GTPBP1 GTP binding protein 1".

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GTPBP1

Related Research Articles

References

Further reading