GZMB

GZMB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FQ3, 1IAU
Identifiers
Aliases	GZMB , CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDs	OMIM: 123910; MGI: 109267; HomoloGene: 108184; GeneCards: GZMB; OMA:GZMB - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q12 Start 24,630,954 bp [1] End 24,634,267 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 C3|14 28.19 cM Start 56,496,295 bp [2] End 56,499,717 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood mononuclear cell monocyte spleen bone marrow decidua lymph node right lung appendix Top expressed in gastrula jejunum duodenum decidua blood intestinal villus embryo pharynx uterus seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity protein binding serine-type peptidase activity serine-type endopeptidase activity hydrolase activity Cellular component cytosol membrane immunological synapse nucleus mitochondrion secretory granule cytoplasm Biological process cytolysis proteolysis positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway natural killer cell mediated cytotoxicity apoptotic process granzyme-mediated apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3002 14939 Ensembl ENSG00000100453 ENSMUSG00000015437 UniProt P10144 P04187 RefSeq (mRNA) NM_004131 NM_001346011 NM_013542 RefSeq (protein) NP_001332940 NP_004122 NP_038570 Location (UCSC) Chr 14: 24.63 – 24.63 Mb Chr 14: 56.5 – 56.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Granzyme B is a serine protease that in humans is encoded by the GZMB gene. ^[5] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. ^[6]

See also

• The Proteolysis Map
• Granzyme

References

1. GRCh38: Ensembl release 89: ENSG00000100453 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015437 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID   2323780. S2CID   22245529.
6. "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

Further reading

• Trapani JA (1996). "Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.". Australian and New Zealand Journal of Medicine. 25 (6): 793–9. doi:10.1111/j.1445-5994.1995.tb02883.x. PMID   8770355.
• Cohen GM (1997). "Caspases: the executioners of apoptosis". Biochem. J. 326 (1): 1–16. doi:10.1042/bj3260001. PMC   1218630 . PMID   9337844.
• Trapani JA, Sutton VR (2004). "Granzyme B: pro-apoptotic, antiviral and antitumor functions". Curr. Opin. Immunol. 15 (5): 533–43. doi:10.1016/S0952-7915(03)00107-9. PMID   14499262.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.010 ^{[ permanent dead link ]}